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Prox1-Flox

SKU : BHAM00244

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-CKO-2102305
Description	Model Description: These mice carry loxP sites flanking exon 2 of Prox1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Prox1 gene. Official Symbol: Prox1 NCBI ID: 19130 MGI ID: 97772 Ensembl ID: ENSMUSG00000010175 Pubmed: Prox1 Human Ortholog: PROX1
Nomenclature	C57BL/6JSmoc-Prox1^{tm1(flox)Smoc}
Exon	Exon 2
Disease	Dilated Cardiomyopathy
Disease	Cardio-metabolic Disease
KI/KO Gene	Prox1
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Nkx2-5-Cre mice.
Synonyms	PROX-1, A230003G05Rik

Reference	MGI:2684657 Petchey LK, Risebro CA, Vieira JM, Roberts T, Bryson JB, Greensmith L, Lythgoe MF, Riley PR, Loss of Prox1 in striated muscle causes slow to fast skeletal muscle fiber conversion and dilated cardiomyopathy. Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9515-20

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