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Lmx1a-Flox

SKU : BHAM00165

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	TBD
Description	Model Description: These mice carry loxP sites flanking target exons of Lmx1a gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Lmx1a gene. Official Symbol: Lmx1a NCBI ID: 110648 MGI ID: 1888519 Ensembl ID: ENSMUSG00000026686 Pubmed: Lmx1a Human Ortholog: LMX1A
Nomenclature	C57BL/6JSmoc-Lmx1a^{em1(flox)Smoc}
Exon	Exon s
Disease	Parkinson's Disease
Disease	Nervous System Disease
KI/KO Gene	Lmx1a
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Lmx1b-Flox(NM-CKO-200117) and Slc6a3-cre mice.
Synonyms	dr, sst, Lmx1.1, dreher

Reference	MGI:3715141 Laguna A, Schintu N, Nobre A, Alvarsson A, Volakakis N, Jacobsen JK, Gomez-Galan M, Sopova E, Joodmardi E, Yoshitake T, Deng Q, Kehr J, Ericson J, Svenningsson P, Shupliakov O, Perlmann T, Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease. Nat Neurosci. 2015 Jun;18(6):826-35

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