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Kras-LSL-G12D

SKU : BHAM00154

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-KI-190003
Description	Model Description: exon2 of Kras were replaced by loxp-stop-loxp and exon2 containing G12D. When crossed with a Cre recombinase-expressing strain, this strain is useful in studies of cancer and development. Official Symbol: Kras NCBI ID: 16653 MGI ID: 96680 Ensembl ID: ENSMUSG00000030265 Pubmed: Kras Human Ortholog: KRAS
Nomenclature	C57BL/6JSmoc-Kras^{em4(LSL-G12D)Smoc}
Exon	Exon 2
Application	Cancer Research
Disease	Squamous Cell Carcinoma
Disease	Spontaneous Tumor
KI/KO Gene	Kras
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Smad4-Flox(NM-CKO-18011) and Krt1-15-cre mice.
Synonyms	Ki-ras K-ras Kras2 Kras-2

Reference	MGI:2653129 White RA, Neiman JM, Reddi A, Han G, Birlea S, Mitra D, Dionne L, Fernandez P, Murao K, Bian L, Keysar SB, Goldstein NB, Song N, Bornstein S, Han Z, Lu X, Wisell J, Li F, Song J, Lu SL, Jimeno A, Roop DR, Wang XJ, Epithelial stem cell mutations that promote squamous cell carcinoma metastasis. J Clin Invest. 2013 Oct 1;123(10):4390-404

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