Model Description: These Hnf4a flox mice possess loxP sites flanking exon 2. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.
Official Symbol: Hnf4a
NCBI ID: 15378
MGI ID: 109128
Ensembl ID: ENSMUSG00000017950
Pubmed: Hnf4a
Human Ortholog: HNF4A
Nomenclature
C57BL/6JSmoc-Hnf4atm1(flox)Smoc
Exon
Exon 2.
Application
Transcriptional Regulator, Insulin Secretion Related
Disease
Fanconi Syndrome
Disease
Cardio-metabolic Disease
KI/KO Gene
Hnf4a
Notes
Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Six2-cre mice.
Marable SS, Chung E, Adam M, Potter SS, Park JS, Hnf4a deletion in the mouse kidney phenocopies Fanconi renotubular syndrome. JCI Insight. 2018 Jul 25;3(14)