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Flvcr1-Flox

SKU : BHAM00092

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-CKO-200054
Description	Model Description: These mice carry loxP sites flanking exon 3 of Flvcr1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Flvcr1 gene. Official Symbol: Flvcr1 NCBI ID: 226844 MGI ID: 2444881 Ensembl ID: ENSMUSG00000066595 Pubmed: Flvcr1 Human Ortholog: FLVCR1
Nomenclature	C57BL/6JSmoc-Flvcr1^{em1(flox)Smoc}
Exon	Exon 3
Application	Diseases Associated With Flvcr1 Include Posterior Column Ataxia With Retinitis Pigmentosa And Posterior Column Ataxia.
Disease	Diamond-Blackfan Anemia
Disease	Rare Disease
KI/KO Gene	Flvcr1
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Mx1-cre mice.
Synonyms	FLVCR, Mfsd7b, 9630055N22Rik

Reference	Colin T. Dolphin, Azara Janmohamed, Robert L. Smith, Elizabeth A. Shephard & lan R. Phillips. Missense mutation in flavin-containing mono-oxygenase 3 gene, FMO3, underlies fish-odour syndrome. Nature Genetics volume 17, pages491494 (1997) Keel SB, Doty RT, Yang Z, Quigley JG, Chen J, Knoblaugh S, Kingsley PD, De Domenico I, Vaughn MB, Kaplan J, Palis J, Abkowitz JL, A heme export protein is required for red blood cell differentiation and iron homeostasis. Science. 2008 Feb 8;319(5864):825-8

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