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Ext1-Flox

SKU : BHAM00082

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	TBD
Description	Model Description: These mice carry loxP sites flanking target exons of Ext1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ext1 gene. Official Symbol: Ext1 NCBI ID: 14042 MGI ID: 894663 Ensembl ID: ENSMUSG00000061731 Pubmed: Ext1 Human Ortholog: EXT1
Nomenclature	C57BL/6JSmoc-Ext1^{em1(flox)Smoc}
Exon	Exon s
Disease	Hereditary Multiple Exostoses
Disease	Nervous System Disease
KI/KO Gene	Ext1
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Col2a1-rtTA,tetO-cre mice.
Synonyms	AA409028

Reference	MGI:2449544 Jones KB, Piombo V, Searby C, Kurriger G, Yang B, Grabellus F, Roughley PJ, Morcuende JA, Buckwalter JA, Capecchi MR, Vortkamp A, Sheffield VC, A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2054-9

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