Model Description: These mice carry loxP sites flanking target exons of Esrrb gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Esrrb gene.
Official Symbol: Esrrb
NCBI ID: 26380
MGI ID: 1346832
Ensembl ID: ENSMUSG00000021255
Pubmed: Esrrb
Human Ortholog: ESRRB
Nomenclature
C57BL/6JSmoc-Esrrbem1(flox)Smoc
Exon
Exon s
Disease
Dilated Cardiomyopathy
Disease
Cardio-metabolic Disease
KI/KO Gene
Esrrb
Notes
Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Myh6-cre mice.
Rowe GC, Asimaki A, Graham EL, Martin KD, Margulies KB, Das S, Saffitz J, Arany Z, Development of dilated cardiomyopathy and impaired calcium homeostasis with cardiac-specific deletion of ESRRbeta. Am J Physiol Heart Circ Physiol. 2017 Apr 01;312(4):H662-H671