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Erbb2-Flox

SKU : BHAM00084

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-CKO-220557
Description	Model Description: These mice carry loxP sites flanking exon 2 of Erbb2 When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Erbb2 gene. Official Symbol: Erbb2 NCBI ID: 13866 MGI ID: 95410 Ensembl ID: ENSMUSG00000062312 Pubmed: Erbb2 Human Ortholog: ERBB2
Nomenclature	C57BL/6JSmoc-Erbb2^{em(flox)/Smoc}
Exon	Exon 2
Disease	Breast Cancer
Disease	Cardio-metabolic Disease
KI/KO Gene	Erbb2
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Pten-Flox(NM-CKO-18004) and MMTV-cre mice.
Synonyms	Neu, HER2, HER-2, c-neu, Erbb-2, c-erbB2, l11Jus8, mKIAA3023

Reference	MGI:5905569 Dourdin N, Schade B, Lesurf R, Hallett M, Munn RJ, Cardiff RD, Muller WJ, Phosphatase and tensin homologue deleted on chromosome 10 deficiency accelerates tumor induction in a mouse model of ErbB-2 mammary tumorigenesis. Cancer Res. 2008 Apr 1;68(7):2122-31

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