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Egln1-Flox

SKU : BHAM00088

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-CKO-2100497
Description	Model Description: These mice carry loxP sites flanking exon 2-3 of Egln1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Egln1 gene. Official Symbol: Egln1 NCBI ID: 112405 MGI ID: 1932286 Ensembl ID: ENSMUSG00000031987 Pubmed: Egln1 Human Ortholog: EGLN1
Nomenclature	C57BL/6JSmoc-Egln1^{em1(flox)Smoc}
Exon	Exon 2-3
Disease	Cardiomyopathy
Disease	Cardio-metabolic Disease
KI/KO Gene	Egln1
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Egln3-Flox(NM-CKO-2108727) and Myh6-cre mice.
Synonyms	Phd2, HPH-2, ORF13, SM-20, C1orf12, HIF-PH2, AI503754, Hif-p4h-2

Reference	MGI:5304713 Moslehi J, Minamishima YA, Shi J, Neuberg D, Charytan DM, Padera RF, Signoretti S, Liao R, Kaelin WG Jr, Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy. Circulation. 2010 Sep 7;122(10):1004-16

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