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Dot1l-Flox

SKU : BHAM00071

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	TBD
Description	Model Description: These mice carry loxP sites flanking target exons of Dot1l gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Dot1l gene. Official Symbol: Dot1l NCBI ID: 208266 MGI ID: 2143886 Ensembl ID: ENSMUSG00000061589 Pubmed: Dot1l Human Ortholog: DOT1L
Nomenclature	C57BL/6JSmoc-Dot1l^{em1(flox)Smoc}
Exon	Exon s
Disease	Dilated Cardiomyopathy 1A
Disease	Cardio-metabolic Disease
KI/KO Gene	Dot1l
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Myhca-cre mice.
Synonyms	Dot1, KMT4, mDot1, AW907654, A630076O07

Reference	MGI:5285873 Nguyen AT, Xiao B, Neppl RL, Kallin EM, Li J, Chen T, Wang DZ, Xiao X, Zhang Y, DOT1L regulates dystrophin expression and is critical for cardiac function. Genes Dev. 2011 Feb 1;25(3):263-74

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