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Cdkal1-Flox

SKU : BHAM00043

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	TBD
Description	Model Description: These mice carry loxP sites flanking target exons of Cdkal1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Cdkal1 gene. Official Symbol: Cdkal1 NCBI ID: 68916 MGI ID: 1921765 Ensembl ID: ENSMUSG00000006191 Pubmed: Cdkal1 Human Ortholog: CDKAL1
Nomenclature	C57BL/6JSmoc-Cdkal1^{em1(flox)Smoc}
Exon	Exon s
Disease	Type 2 Diabetes Mellitus
Disease	Cardio-metabolic Disease
KI/KO Gene	Cdkal1
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Ins2-cre mice.
Synonyms	1190005B03Rik, 6620401C13Rik

Reference	MGI:5574073 Wei FY, Suzuki T, Watanabe S, Kimura S, Kaitsuka T, Fujimura A, Matsui H, Atta M, Michiue H, Fontecave M, Yamagata K, Suzuki T, Tomizawa K, Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice. J Clin Invest. 2011 Sep 1;121(9):3598-608

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