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Apc-L850X

SKU : BHAM00013

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-KI-200001
Description	Model Description: Familial adenomatous polyposis (FAP) is a heritable condition in which affected individuals develop benign intestinal polyps. Often, polyps progress to colorectal carcinomas later in life. The mutation of C57BL/6-Apcem1(L850X)Smoc(NM-KI-200001) strain of SMOC refers to the ApcMin model (Jax: 002020 ), a useful model to study intestinal adenomas. The C57BL/6-Apcem1(L850X)Smoc strain is highly susceptible to spontaneous intestinal adenoma formation and can be used as a research model for human FAP. These mice carry a p.L850X mutation of Apc gene. Official Symbol: Apc NCBI ID: 11789 MGI ID: 88039 Ensembl ID: ENSMUSG00000005871 Pubmed: Apc Human Ortholog: APC
Nomenclature	C57BL/6JSmoc-Apc^{em1(L850X)Smoc}
Application	Heterozygotes Of This Strain Are Highly Susceptible To Spontaneous Intestinal Adenoma Formation. Homozygous Mice Are Not Viable.
Disease	familial adenomatous polyposis
KI/KO Gene	Apc
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Rab25-KO(NM-KO-191148) mice.
Synonyms	CC1, Min, mAPC, AI047805, AU020952, AW124434

Reference	Carl B Gillombardo, Rebecca Darrah, Thomas E Dick, Michael Moore ,C57BL/6J mouse apolipoprotein A2 gene is deterministic for apnea. Respir Physiol Neurobiol. 2017 Jan;235:88-94. Nam KT, Lee HJ, Smith JJ, Lapierre LA, Kamath VP, Chen X, Aronow BJ, Yeatman TJ, Bhartur SG, Calhoun BC, Condie B, Manley NR, Beauchamp RD, Coffey RJ, Goldenring JR, Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas. J Clin Invest. 2010 Mar;120(3):840-9

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