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Apc-Flox

SKU : BHAM00014

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-CKO-200013
Description	Model Description: These mice carry loxP sites flanking exon 15 of Apc gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Apc gene. Official Symbol: Apc NCBI ID: 11789 MGI ID: 88039 Ensembl ID: ENSMUSG00000005871 Pubmed: Apc Human Ortholog: APC
Nomenclature	C57BL/6JSmoc-Apc^{tm2(flox)Smoc}
Exon	Exon 15
Application	Intestinal Tumor Research
Disease	Colorectal Cancer
Disease	Spontaneous Tumor
KI/KO Gene	Apc
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Vil1-cre/ERT2 mice.
Synonyms	CC1, Min, mAPC, AI047805, AU020952, AW124434

Reference	MGI:4440863 Levy J, Cacheux W, Bara MA, L'Hermitte A, Lepage P, Fraudeau M, Trentesaux C, Lemarchand J, Durand A, Crain AM, Marchiol C, Renault G, Dumont F, Letourneur F, Delacre M, Schmitt A, Terris B, Perret C, Chamaillard M, Couty JP, Romagnolo B, Intestinal inhibition of Atg7 prevents tumour initiation through a microbiome-influenced immune response and suppresses tumour growth. Nat Cell Biol. 2015 Aug;17(8):1062-73

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