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Home / Primary Antibodies / Conjugated Primary Antibodies

E2F4 Antibody, HRP conjugated

SKU : BHA10530145

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA00759B0Rb
Alternative Names	Transcription factor E2F4 (E2F-4), E2F4
Categories	Primary Antibodies
Clonality	polyclonal
Description	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.
Host	Rabbit
Immunogen	Recombinant Human Transcription factor E2F4 protein (160-299AA)
Isotype	IgG
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.
Species	Homo Sapiens (Human)
Subcellular Location	Nucleus

Uniprot	Q16254
Database Links	HGNC:3118 OMIM:600659 KEGG:hsa:1874 STRING:9606.ENSP00000368686 UniGene:Hs.108371
Function	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation
Pathway	TGF-beta signaling pathway Cell cycle Cellular senescence
Protein Families	E2F/DP family
Research Area	Epigenetics and Nuclear Signaling
Tissue Specificity	Found in all tissue examined including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form	Liquid
Format	Liquid
Purification	>95%, Protein G purified
Purity	>95%,Protein G purified
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Applications	ELISA
Description	ELISA
Tested Application	ELISA

Datasheet
ELISA Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10530145	CSB-PA00759B0Rb	100ug	$299		Add to Cart
BHA10530145	CSB-PA00759B0Rb	50ug	$166		Add to Cart

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