Mouse Anti-Rat Clcn3 Monoclonal IgG1

Mfr.No.	SMC-408, SMC-408D, SMC-408D-A390, SMC-408D-A488, SMC-408D-A594, SMC-408D-APC, SMC-408D-BI, SMC-408D-FITC, SMC-408D-HRP, SMC-408D-PCP, SMC-408D-RPE, SMC-408S
Immunogen Species	Rat
Alternative Names	CIC3 Antibody, CLC3 Antibody, CLCN 3 Antibody, Chloride channel 3 Antibody, Chloride channel protein 3 Antibody, Chloride channel Antibody, voltage-sensitive 3 Antibody, Chloride transporter ClC 3 Antibody, DKFZp564I0463 Antibody, H(+)/Cl(-) exchange transporter 3 Antibody, Chloride transporter ClC-3 Antibody, ClC-3 Antibody, H(+)/Cl(-) exchange transporter 3 Antibody
Categories	Antibodies
Cellular Localization	Membrane, Endosome, Endosome membrane, Cytoplasmic Vesicle, Secretory Vesicle Membrane
Certificate Of Analysis	1 ug/ml of SMC-408 was sufficient for detection of Clcn3 in 20 ug of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Clonality	Monoclonal
Description	Mouse Anti-Rat Clcn3 Monoclonal IgG1
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Mouse
Gross Weight (kg)	1.4
Immunogen	Synthetic peptide amino acids 98-115 (cytoplasmic N-terminus) of rat Clcn3, Rattus Norvegicus (Rat)
Immunogen Region	Synthetic peptide amino acids 98-115 (cytoplasmic N-terminus) of rat Clcn3
Isotype	IgG1
Launch Date	2012/05/16
Net Weight (g)	0.1
Reactivity	Rat, Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Species	Rattus Norvegicus (Rat)
Species Reactivity Medium	Mouse, Rat, Human

Antigen	ClCN3
Swissprot	P51792
Accession Number	NP_445815.2
Gene Id	84360
Target	ClCN3
Clone No	S258-5
Research Area	Pumps/Transporters, Cell Signaling, Ion Pumps/Transporters, Neuroscience

Buffer	PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration	1 mg/ml
Dilutions	WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification	Protein G Purified
Scientific Background	Clcn3 mediates the exchange of chloride ions against protons, and functions as an antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. It may play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could also help neuronal cells to establish short-term memory.
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~90kDa. Does not cross-react with Clcn4 or Clcn5 (based on KO validation results).
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	IHC, WB, ICC/IF
Description	WB ; IHC ; ICC ; IF
Dilution	WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. www.phosphosite.org/proteinAction.do id=5088&showAllSites=true

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11903659-1	SMC-408D	Unconjugated	100 ug	$337	Add to Cart
BHA11903659-2	SMC-408D-A390	ATTO 390	100 ug	$392	Add to Cart
BHA11903659-3	SMC-408D-A488	ATTO 488	100 ug	$391	Add to Cart
BHA11903659-4	SMC-408D-A594	ATTO 594	100 ug	$391	Add to Cart
BHA11903659-5	SMC-408D-APC	APC	100 ug	$390	Add to Cart
BHA11903659-6	SMC-408D-BI	Biotin	100 ug	$386	Add to Cart
BHA11903659-7	SMC-408D-FITC	FITC	100 ug	$381	Add to Cart
BHA11903659-8	SMC-408D-HRP	HRP	100 ug	$377	Add to Cart
BHA11903659-9	SMC-408D-PCP	PerCP	100 ug	$390	Add to Cart
BHA11903659-10	SMC-408D-RPE	RPE	100 ug	$388	Add to Cart
BHA11903659-11	SMC-408S	Unconjugated	12 ug	$45	Add to Cart

Clcn3 Antibody, Clone N258/5 (SMC-408)