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Home / Biochemicals / Small Molecules

Chlormethiazole hydrochloride

SKU : BHB21300099

A Positive Modulator of GABA(A) and Glycine Receptors

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Mfr.No.	C-360, C-360_1 g, C-360_100 mg, C-360_250 mg, C-360_50 mg, C-360_500 mg
Description	Chlormethiazole hydrochloride (#C-360) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C₆H₉Cl₂NS.
Synonyms	Synthetic
Background	Chlormethiazole hydrochloride, a thiazole derivative, is a sedative, hypnotic and anxiolytic compound that has been used for the treatment of alcohol-withdrawal symptoms, status epilepticus and pre-eclampsia.Chlormethiazole acts as a positive modulator of GABA(A) and glycine receptors and holds structural similarity to the beta-subunit-selective compound loreclezole. In several studies, the compound was also shown to have neuroprotective properties in models of ischaemia1,2,3.GABA(A) receptors are members of the Cys-loop superfamily of ligand-gated ion channels and mediate GABA action, a major inhibitory neurotransmitter, throughout the central nervous system. GABA(A) receptors are considered to be a major target of antiseizure drugs4.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.01-1 mM.
Reconstitution	Up to 200 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	6001-74-7
Molecular Weight	198.11
Solubility	Up to 200 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Target	GABA(A), Glycine receptors
Activity	Chlormethiazole both directly activates GABAA receptors (at 0.3 - 1 mM), and potentiates GABA-induced activation at various GABAA receptor subtypes (with EC50 of 20 - 160 uM)1. It was also shown to potentiate glycine-induced currents in both bovine chromaffin cells and murine spinal neurons (at 100 uM)2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 5-(2-chloroethyl)-4-methyl-1,3-thiazole;hydrochloride.

Purity	>96%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Up to four weeks at 4°C or three months at -20°C. It is recommended to aliquot reconstituted product for storage.

Product Manual	SDS

Reference	Usala, M. et al. (2003) Br. J. Pharmacol. 140, 1045. Vandevred, L. et al. (2014) Br. J. Pharmacol. 171, 389. Wilby, M.J. and Hutchinson, P.J. (2004) CNS Drug Rev. 10, 281. Nohria, V. and Giller, E. (2007) Neurotherapeutics 4, 102. Usala, M. et al. (2003) Br. J. Pharmacol. 140, 1045. Hales, T.G. and Lambert, J.J. (1992) Eur. J. Pharmacol. 210, 239.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300099-1	C-360_1 g	1 g	$287		Add to Cart
BHB21300099-2	C-360_100 mg	100 mg	$85		Add to Cart
BHB21300099-3	C-360_250 mg	250 mg	$117		Add to Cart
BHB21300099-4	C-360_50 mg	50 mg	$66		Add to Cart
BHB21300099-5	C-360_500 mg	500 mg	$168		Add to Cart

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