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Home / Primary Antibodies

CHD5 Antibody / Chromodomain-helicase-DNA-binding protein 5

SKU : BHA17102536

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NSJ Bioreagents

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Mfr.No.	F53930
Clonality	Polyclonal
Description	Chromodomain-helicase-DNA-binding protein 5 is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non- methylated 'Lys-4' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys- 27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in tu, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa.
Formulation	In 1X PBS, pH 7.4, with 0.09% sodium azide
Host	Rabbit
Immunogen Region	A portion of amino acids 64-98 from the human protein was used as the immunogen for the CHD5 antibody.
Isotype	Ig
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Uniprot	Q8TDI0
Gene Id	26038

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	Aliquot the CHD5 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Applications	WB
Dilution	Weste blot: 1:1000-2000

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17102536	F53930	0.05 ml	$155		Add to Cart

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