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SLC5A5 - HEK293 Recombinant Cell line

SKU : BHC18200235

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BPS Bioscience

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Mfr.No.	90333
Description	Stable recombinant HEK293 cell line expressing human SLC5A5 (UniProt # Q92911) with a C-terminalFLAG- tag. SLC5A5 is a sodium-dependent iodide transporter and is a member of thesodium glucose co-transporter family. The expression of SLC5A5 is confirmed by Westernblotting. This cell line can be used to evaluate agents that may affect iodide transport. Host Species: human
Background	Iodine transport is essential for the production of thyroid hormone (T4). Sodium IodideSymporter SLC5A5 (NIS) is a sodium-dependent transporter of iodide into thyroid follicular cellsand other peripheral tissues to support T4 synthesis (1). Lack of iodide transport can result inhypothyroidism and can manifest itself in several disease states like goiter formation and weightgain. SLC5A5 also plays an important role in hyperthyroidism (an excessive production of T4).Expression and activity of SCL5A5 is altered in several forms of cancer. Inhibitors of SLC5A5have potential therapeutic benefit for the regulation of iodine overload induced by amiodaroneor other thyromimetics that can result in hyperthyroidism (2).
Application	Drug compound screening, Functional assays
Host Cell	HEK293
Uniprot	Q92911
Shipping Temperature	-80°C (dry ice)
Note	License Disclosure: Purchase of this cell line grants you with a 10-year license to use this cell line in your immediate laboratory, for research use only. This license does not permit you to share, distribute, sell, sublicense, or otherwise make the cell line available for use to other laboratories, departments, research institutions, hospitals, universities, or biotech companies. The license does not permit use of this cell line in humans or for therapeutic or drug use. The license does not permit modification of the cell line in any way. Inappropriate use or distribution of this cell line will result in revocation of the license and result in an immediate cease of sales and distribution of Biohippo products to your laboratory. Biohippo does not warrant the suitability of the cell line for any particular use, and does not accept any liability in connection with the handling or use of the cell line. Modifications of this cell line, transfer to another facility, or commercial use of the cells may require a separate license and additional fees; contact orders@biohippo.com for details. Publications using this cell line should reference Biohippo Inc. Warning: Avoid freeze/thaw cycles.

Product Format	Each vial contains ~1.5 X 10^6 cells in 1 ml of 10% DMSO.
Storage Stability	Immediately upon receipt, store in liquid nitrogen.

Reference	1. Dohan et al., (2003) The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance. Endocrine Reviews 24(1):48-77. 2. Lindenthal et al., (2009) Characterization of NIS inhibitors. Journal of Endocrinology 200: 357-365. 3. Waltz et al., (2010) A nonradioactive iodide uptake assay for sodium iodide symporter function. Analytical Biochemistry 396(1): 91-5.

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200235	90333	2 vials	$10340		Add to Cart

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