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Home / Cells / Cell Lines

PD-1 / NFAT Reporter - Jurkat Cell Line

SKU : BHC18200026

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BPS Bioscience

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Mfr.No.	60535
Description	Recombinant Jurkat T cell expressing firefly luciferase gene under the control of NFAT response elements with constitutive expression of human PD-1 (Programmed Cell Death 1, PDCD1, SLEB2, CD279, GenBank Accession #NM_005018). Mycoplasma testing: The cell line has been screened using the PCR-based VenorGeM Mycoplasma Detection kit (Sigma-Aldrich) to confirm the absence of Mycoplasma species. Host Species: human Supplied as Each vial contains 2 X 106 cells in 1 ml of 10% DMSO
Background	The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated Tcells,to its ligands, PD-L1 and PD-L2, negatively regulates immune responses. The PD-1ligands are found on most cancers, and PD-1:PD-L1/2 interaction inhibits T cell activity andallows cancer cells to escape immune surveillance. The PD-1:PD-L1/2 pathway is also involvedin regulating autoimmune responses, making these proteins promising therapeutic targets for anumber of cancers, as well as multiple sclerosis, arthritis, lupus, and type I diabetes.
Application	Screen for activators or inhibitors of PD-1 signaling in a cellular context Characterize the biological activity of PD-1 and its interactions with ligands
Host Cell	Jurkat
Synonyms	Programmed cell death 1, PDCD1, PD-1, PD1, SLEB2, CD279, HPD-L, PD1/NFAT, PD-1 NFAT, PD-1/NFAT
Shipping Temperature	-80°C (dry ice)

Product Format	Aqueous solution containing DMSO
Storage Stability	Immediately upon receipt, store in liquid nitrogen.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200026	60535	2 vials	$12512.50		Add to Cart

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