Notch Signaling Pathway Notch1/CSL Report Cell Line-HEK293

Mfr.No.	ABC-RC123D
Description	The Notch CSL Reporter &ndash; HEK293 cell line contains the firefly luciferase gene under the control of Notch-response elements (CSL responsive elements) alone with expression construct for Notch1 E (NOTCH1 that has a deletion of the entire extracellular domain) stably integrated into HEK293 cells. Inside the cells, the Notch1 E can be cleaved by &gamma;-secretase. The active Notch1 NICD is released to nucleus and induces the constitutive expression of luciferase reporter. The cell line is validated for the inhibition of the expression of luciferase reporter using a known inhibitor of the Notch signaling pathway.
Categories	Transfected Stable Cell Lines
Application	For research use only
Host Cell	HEK293 cells
Species	Human

Shipping	Dry Ice
Storage	Liquid Nitrogen

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