Human Peripheral Blood CD14+ Monocytes

Product Description

Monocytes are innate blood cells that maintain vascular homeostasis and are early responders to pathogens in acute infections ^{(1, 2)}.  Monocytes constitute 10~30% of peripheral blood mononuclear cells in the human body. They play multiple roles in immune function including replenishing resident macrophages under normal states. And in response to inflammation signals, monocytes can move quickly (approx. 8–12 hours) to sites of infection in the tissues and divide/differentiate into macrophages and dendritic cells to elicit an immune response ⁽³⁾. CD14 is an important surface marker for monocytes.

iXCells Biotechnologies offers Human Peripheral Blood Pan Monocytes (Untouched) isolated from normal human peripheral blood mononuclear cells (PBMCs) using negative immunomagnetic selection (Kopelsonclinic).  > 85% of the cells are CD14+ as showed by flow cytometric analysis.

Figure 1. The representative flow cytometry analysis result of Human Peripheral Blood Pan Monocytes (Untouched).

Product Details

References

(1) Martin Guilliams, Alexander Mildner, and Simon Yona. (2018) “Developmental and Functional Heterogeneity of Monocytes”. Immunity, 49: 595-613.

(2) Prakash Babu Narasimhan, Paola Marcovecchio, Anouk A.J. Hamers, and Catherine C. Hedrick. (2019) “Nonclassical Monocytes in Health and Disease”. Annual Reviews of Immunology, 37: 439-456.

(3) Ziegler-Heitbrock, L (2007). "The CD14+ CD16+ Blood Monocytes: their Role in Infection and Inflammation, Review". J Leukocyte Biology 81 (3): 584–92.

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