GR-GAL4 Report Cell Line(Luc)-HEK293

Mfr.No.	ABC-RC114D
Description	The Glucocorticoid Receptor Pathway GAL4 Reporter (Luc) HEK293 Cell Line contains a firefly luciferase gene under the control of glucocorticoid receptor ligand binding domain that is fused to the DNA binding domain (DBD) of GAL4 (GAL4 DBD-GR) stably integrated into HEK293 cells. This fusion construct activates firefly luciferase expression under the control of a multimerized GAL4 upstream activation sequence (UAS). This allows for specific detection of glucocorticoid-induced activation of the glucocorticoid receptor without the need for individual transcriptional targets and with low cross-reactivity for other nuclear receptor pathways. This cell line is validated for response to stimulation of DXMS and to the treatment with mifepristone, an inhibitor of the glucocorticoid signaling pathway.
Categories	Transfected Stable Cell Lines
Application	For research use only
Host Cell	HEK293
Species	Human

Shipping	Dry Ice
Storage	Liquid Nitrogen

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