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Home / Cells / Cell Lines

SIRPalpha / HEK293 Recombinant Cell Line

SKU : BHC18200064

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BPS Bioscience

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Mfr.No.	60689
Description	Recombinant HEK293 cell constitutively expressing full length human SIRPalpha (#NM_080792). Surface expression is confirmed by flow cytometry. Mycoplasma testing: This cell line has been screened using the MycoAlert (Cat. #LT07-118) to confirm the absence of Mycoplasma contamination. MycoAlert Assay Control Set (Cat # LT07-518) was used as a positive control. Host Species: human
Background	SIRPalpha (CD172A, PTPNS1) is a member of the signal-regulatory-protein (SIRP) family, which are transmembrane immunoglobulin receptors that negatively regulate receptor tyrosine kinase-coupled signaling processes. SIRPalpha is expressed predominantly on macrophages and dendritic cells. Interaction with its ligand CD47 mediates signals that blocks phagocytosis (also known as the "don't eat me" signal).
Application	This cell line is useful for SIRPalpha:CD47 protein binding analyses and screening for antibodies or inhibitors of CD47.
Host Cell	HEK293
Shipping Temperature	-80°C (dry ice)
Note	License Disclosure: Purchase of this cell line grants you with a 10-year license to use this cell line in your immediate laboratory, for research use only. This license does not permit you to share, distribute, sell, sublicense, or otherwise make the cell line available for use to other laboratories, departments, research institutions, hospitals, universities, or biotech companies. The license does not permit use of this cell line in humans or for therapeutic or drug use. The license does not permit modification of the cell line in any way. Inappropriate use or distribution of this cell line will result in revocation of the license and result in an immediate cease of sales and distribution of Biohippo products to your laboratory. Biohippo does not warrant the suitability of the cell line for any particular use, and does not accept any liability in connection with the handling or use of the cell line. Modifications of this cell line, transfer to another facility, or commercial use of the cells may require a separate license and additional fees; contact orders@biohippo.com for details. Publications using this cell line should reference Biohippo Inc.

Product Format	Each vial contains ~2 x 10^6 cells in 1 ml of 10% DMSO in FBS.
Storage Stability	Store in liquid nitrogen immediately upon receipt.

Reference	1. Lee WY et.al. (2010) The Role of cis Dimerization of Signal Regulatory Protein a (SIRPa) in Binding to CD47. J. Biol. Chem. 285: 37953-37963

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200064	60689	2 vials	$5324		Add to Cart

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