This cell line expresses a surface human GITR (glucocorticoid-induced TNFR family related gene; TNFRSF18; CD357) and an NF-B luciferase reporter construct that are stably integrated into the genome of Jurkat T-cells. The firefly luciferase gene is controlled by 4 copies of NF-kB response element located upstream of the TATA promoter. Following activation by stimulants, endogenous NF-B transcription factors bind to the DNA response elements to induce transcription of the luciferase gene.
Categories
Transfected Stable Cell Lines
Application
For research use only
Host Cell
Jurkat
Species
Human
Shipping
Dry Ice
Storage
Liquid Nitrogen
Reviews of GITR/NF-kappaB Luciferase Report Cell Line-Jurkat