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CRE/CREB Luciferase Reporter CHO Cell Line (cAMP/PKA Signaling Pathway)

SKU : BHC18200160

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BPS Bioscience

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Mfr.No.	78568
Description	The CRE/CREB Luciferase Reporter CHO Cell Line (cAMP/PKA Signaling Pathway) contains a firefly luciferase gene under the control of multimerized cAMP response element (CRE) stably integrated into CHO cells. Elevation of the intracellular cAMP level activates cAMP response element binding protein (CREB) to bind CRE and induces the expression of luciferase. This cell line is validated for response to Forskolin. Mycoplasma testing: The cell line has been screened to confirm the absence of Mycoplasma species. Host Species: hamster Supplied as Each vial contains 2 x 10⁶ cells in 1 ml of cell freezing medium (Biohippo #79796)
Background	Cyclic adenosine monophosphate (cAMP) is a second messenger involved in cell signaling that regulates various physiological and pathological processes. cAMP regulates the transcription of target genes by activating protein kinase A (PKA) and the transcription factor cAMP response element-binding protein (CREB), a downstream effector. CRE is the target of many extracellular and intracellular signaling pathways, including cAMP, calcium, GPCR (G-protein coupled receptors), and neurotrophins. In the cAMP/PKA signaling pathway, CREB is activated via PKA-mediated phosphorylation and binds to CRE with a general motif of 5-TGACGTCA-3. The cAMP/PKA/CREB signaling pathway has both tumor-suppressive and tumor-promoting effects in cancer cells and can be useful in studying cancer signaling pathways.
Application	Monitor cAMP/PKA signaling pathway activity. Screen for activators or inhibitors of cAMP/PKA signaling pathway.
Host Cell	CHO-K1 cells, Chinese Hamster Ovary, epithelial-like cells, adherent
Shipping Temperature	-80°C (dry ice)
Note	License Disclosure: Visit Biohippobioscience.com/license for the label license and other key information about this product. Troubleshooting Guide: Visit Biohippobioscience.com/cell-line-faq for detailed troubleshooting instructions. For all further questions, please email orders@biohippo.com. Warning: Avoid freeze/thaw cycles

Storage Stability	Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200160	78568	2 vials	$2354		Add to Cart

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