Vandetanib

Mfr.No.	SIH-483
Alternative Names	N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
Appearance	Yellow solid
Function	VEGFR inhibitor
Inchi	InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
Inchikey	UHTHHESEBZOYNR-UHFFFAOYSA-N
Mode Of Action	Inhibitor
Molecular Formula	C22H24BrFN4O2
Pubchem Cid	3081361
Sd File	C22H24BrFN4O2 APtclcactv07281415142D 0 0.00000 0.00000 54 57 0 0 0 0 0 0 0 0999 V2000 7.1962 -0.9627 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1962 1.0373 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8622 0.5581 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6765 -2.0174 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6534 -4.0172 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5367 -2.5273 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4641 2.0373 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4641 -1.9627 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0000 4.0373 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4041 -2.3011 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9561 -0.9974 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3301 0.5373 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3301 -0.4627 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8047 -2.5073 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7932 -3.5072 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5251 -3.5273 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7321 2.0373 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 3.5373 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8660 2.5373 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7321 4.0373 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4641 1.0373 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 5.4641 -0.9627 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 2.5373 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9214 -3.9972 0.0000 F 0 0 0 0 0 0 0 0 0 0 0 0 8.9561 1.0719 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 9.8622 -0.4836 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 8.9446 -1.9973 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8660 3.5373 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 12.3853 -4.0373 0.0000 Br 0 0 0 0 0 0 0 0 0 0 0 0 8.0622 -0.4627 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0622 0.5373 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1962 -1.5827 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1962 1.6573 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.3979 0.8701 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6837 -1.3974 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6462 -4.6372 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0747 1.9296 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6762 2.6199 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0772 -2.2236 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 1.9173 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8441 -1.9627 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4641 -2.5827 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0841 -1.9627 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3335 1.5623 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1306 1.5623 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2087 3.4296 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8101 4.1199 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2554 2.6449 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6540 1.9546 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1306 4.5122 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3335 4.5122 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3100 4.5742 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4631 4.3473 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6900 3.5003 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 16 29 1 0 0 0 0 15 24 1 0 0 0 0 12 21 1 0 0 0 0 7 21 1 0 0 0 0 13 22 1 0 0 0 0 8 22 1 0 0 0 0 11 27 1 0 0 0 0 14 27 1 0 0 0 0 25 31 1 0 0 0 0 3 25 2 0 0 0 0 11 26 2 0 0 0 0 3 26 1 0 0 0 0 19 28 1 0 0 0 0 20 28 1 0 0 0 0 9 28 1 0 0 0 0 30 31 1 0 0 0 0 11 30 1 0 0 0 0 1 30 2 0 0 0 0 2 31 2 0 0 0 0 12 13 2 0 0 0 0 2 12 1 0 0 0 0 1 13 1 0 0 0 0 14 15 1 0 0 0 0 4 14 2 0 0 0 0 5 15 2 0 0 0 0 4 6 1 0 0 0 0 5 16 1 0 0 0 0 7 23 1 0 0 0 0 6 16 2 0 0 0 0 17 23 1 0 0 0 0 18 23 1 0 0 0 0 17 19 1 0 0 0 0 18 20 1 0 0 0 0 10 27 1 0 0 0 0 1 32 1 0 0 0 0 2 33 1 0 0 0 0 3 34 1 0 0 0 0 4 35 1 0 0 0 0 5 36 1 0 0 0 0 7 37 1 0 0 0 0 7 38 1 0 0 0 0 6 39 1 0 0 0 0 23 40 1 0 0 0 0 8 41 1 0 0 0 0 8 42 1 0 0 0 0 8 43 1 0 0 0 0 17 44 1 0 0 0 0 17 45 1 0 0 0 0 18 46 1 0 0 0 0 18 47 1 0 0 0 0 19 48 1 0 0 0 0 19 49 1 0 0 0 0 20 50 1 0 0 0 0 20 51 1 0 0 0 0 9 52 1 0 0 0 0 9 53 1 0 0 0 0 9 54 1 0 0 0 0 M END $$$$
Research Area	Cell Signaling ; Cancer ; Apoptosis ; Cardiovascular System ; Cancer Growth Inhibitors ; Growth Factor Receptor Inhibitors
Safety Phrases	Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Smiles	C1=C3C(=CC(=C1OC)OCC2CCN(CC2)C)N=CN=C3NC4=CC=C(Br)C=C4F
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	443913-73-3
Molecular Weight	475.4
Scientific Background	Vandetanib is a specific inhibitor of Flk-1 and Flt-4.
Solubility	Soluble in DMSO (30 mg/ml) or EtOH (10 mg/ml)
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.01
Purity	≥98% (HPLC)
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Bruns C.J., et al. (2000) Clin. Cancer. Res: J. Am. Assoc. Cancer Res. 6(5): 1936–1948.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900266-1	SIH-483-10MG	10 mg	$56		Add to Cart
BHB11900266-2	SIH-483-50MG	50 mg	$224		Add to Cart

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