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IHMT-EZH2-426

SKU : BHB20444145

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Description
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Mfr.No.	T79780
Description	IHMT-EZH2-426 (compound 38) is a potent, covalent degrader of EZH2, demonstrating IC50 values of 1.3 nM for EZH2 wild-type, 1.2 nM for EZH2-A687V, and 1.7-3.5 nM for EZH2-Y641F/Y641N/Y641S mutants. The compound effectively inhibits proliferation in B-cell lymphoma and triple-negative breast cancer (TNBC) cell lines, attributed to its capacity to diminish H3K27me3 and EZH2 levels (1).
Molecular Formula	C31H35FN4O4S
Signaling Pathways	Chromatin/Epigenetic
Molecular Weight	578.7
Target	Histone Methyltransferase

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SKU	Supplier No.	Size	Your price	Quantity
BHB20444145	T79780	5 mg	-		Add to Quote
BHB20444145	T79780	50 mg	-		Add to Quote

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IHMT-EZH2-426

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