Etoposide

Mfr.No.	SIH-244
Alternative Names	(5S,5aR,8aR,9R)-9-(4-Hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-β-D-glucopyranoside
Appearance	White solid
Function	Topoisomerase II inhibitor
Inchi	InChI=1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)1
Inchikey	VJJPUSNTGOMMGY-MRAJQDPKSA-N
Mode Of Action	Inducer
Molecular Formula	C29H32O13
Pubchem Cid	36462
Research Area	Cancer ; Apoptosis
Safety Phrases	Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S53 - Avoid exposure - obtain special instruction before use Risk Phrases: R20/21/22 - Harmful by inhilation, in contact with skin and if swallowed R45 - May cause cancer R62 - Possible risk of impaired fertility R68 - Possible risk of irreversible effects Hazard Phrases: H302-H350 Precautionary Phrases: P201-P308 + P313
Smiles	C[C@@H]1OC[C@@H]2[C@@H](O1)[C@@H]([C@H]([C@@H](O2)O[C@H]3[C@H]4COC(=O)[C@@H]4[C@@H](C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	33419-42-0
Molecular Weight	588.56
Scientific Background	Etoposide inhibits the enzyme topoisomerase II, which unwinds DNA, and be doing so causes the DNA strand to break. Cancer cells are then less likely to be able to repair this damage (1).
Solubility	Soluble to 100 mM in DMSO
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.1
Purity	>98%
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Gordaliza M., et al. (2004) Toxicon. 44(4): 441-459.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900066-1	SIH-244-100MG	100 mg	$56		Add to Cart
BHB11900066-2	SIH-244-500MG	500 mg	$183		Add to Cart

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