Emeguisin A is a depsidone fungal metabolite originally isolated fromE. unguis.1It is active against the bacteriaS. aureusand methicillin-resistantS. aureus(MRSA; MIC = 0.5 ug/ml for both), the fungusC. neoformans(MIC = 0.5 ug/ml), and the protozoanP. falciparum(IC50= 2.2 uM).2