Clodronate Liposomes

Clodronate Liposomes utilize the endocytosis mechanism of macrophages to carry membrane-impermeable clodronate (clodronate) into the cell. In the presence of macrophage lysosomal phosphatase, clodronate dissolved in the aqueous phase of liposomes is released and accumulates inside the cell. When it reaches a certain concentration it can induce the macrophage to enter the apoptotic process, thus functioning as a macrophage scavenger.

Applications

Macrophages depletion

Clodronate Liposomes are suitable for a variety of injection methods, such as intravenous, intraperitoneal, subcutaneous, intranasal and testicular. The injection volume is related to the body weight of the mice, the injection cycle, the injection method and the purpose of the experiment.

Specifications

Components

Shipping and Storage

The product is stored at 4?. Transported in ice packs. Cannot be frozen! Shelf life 6 months.

Documents:

Safety Data Sheet

40337_MSDS_HB250103_EN.pdf

Manuals

40337ES-Clodronate Liposomes-Ver.EN20250103.pdf

Citations & References:

[1