Carfilzomib

Mfr.No.	SIH-544
Alternative Names	(αS)-α-[[2-(4-morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide, PR-17, Carfilzomib, Kyprolis, Carfilzomib (PR-171), PR-171, UNII-72X6E3J5AR
Appearance	White powder
Function	20S Proteasome inhibitor
Inchi	1S/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15,27-28,31-34H,16-26H2,1-5H3,(H,41,46)(H,42,50)(H,43,48)(H,44,49)/
Inchikey	BLMPQMFVWMYDKT-NZTKNTHTSA-N
Mode Of Action	Inhibitor
Molecular Formula	C40H57N5O7
Pubchem Cid	11556711
Research Area	Cancer ; Cancer Growth Inhibitors ; Proteasome Inhibitors
Safety Phrases	Classification: Not WHMIS controlled. Hazard statements: H302 Harmful if swallowed. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statements: P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P280 Wear protective gloves/protective clothing/eye protection/face protection. P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Smiles	O=C([C@]1(C)OC1)[C@H](CC(C)C)NC([C@@H](NC([C@@H](NC([C@H](CCC2=CC=CC=C2)NC(CN3CCOCC3)=O)=O)CC(C)C)=O)CC4=CC=CC=C4)=O
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	868540-17-4
Molecular Weight	719.9
Scientific Background	Carfilzomib / PR-17 is an irreversible proteasome inhibitor that targets the chymotrypsin-like beta5 subunit of 20S proteasome. It can arrest the cell cycle and trigger apoptosis in tumor cell lines.
Solubility	Soluble in DMSO (80 mg/ml), or ethanol (25 mg/ml)
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.025
Purity	>98% (TLC); NMR (Conforms)
Storage Temperature	-20ºC
Stock Product	Y

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900323-1	SIH-544-5MG	5 mg	$78		Add to Cart
BHB11900323-2	SIH-544-25MG	25 mg	$281		Add to Cart

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