Aphidicolin

Mfr.No.	SIH-605
Description	DNA polymerase inhibitor
Alternative Names	(3R,4R,4aR,6aS,8R,9R,11aS,11bS)-Tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta(a)naphthalene-4,9-dimethanol, (from Nigrospora sp.)
Appearance	White powder
Inchi	InChI=1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
Inchikey	NOFOAYPPHIUXJR-APNQCZIXSA-N
Molecular Formula	C20H34O4
Pubchem Cid	457964
Research Area	Cell Signaling \| Epigenetics and Nuclear Signaling \| Neuroscience
Safety Phrases	Classification: Caution: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dustS24/25 - Avoid contact with skin and eyesS36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Smiles	C(C@)12CC(C@H)((C@@)((C@@H)1CC(C@@H)3(C@@)24CC(C@@)((C@H)(C3)C4)(CO)O)(C)CO)O
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	38966-21-1
Molecular Weight	338.5
Scientific Background	Aphidicolin specifically inhibits DNA polymerase Alpha and Delta via binding to the enzyme, in eukaryotic cells such as the HeLa cell line, without affecting other DNA polymerases (1). Arrests cell cycle at early S phase while allowing continued cell growth(2). Potentiates apoptosis induction induced by other agents(3). Increases gene amplification frequency in HeLa S3 cells overexpressing Bcl-2(4).
Solubility	May be dissolved in DMSO (10 mg/ml); or ethanol (1 mg/ml)
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.005
Purity	>98% (TLC), NMR (Conforms)
Storage Temperature	-20°C
Stock Product	Y

Reference	1. Syvaoja J., et al. (1990) Proc. Natl. Acad. Sci. USA. 87(17):6664-6668. 2. Urbani L., et al. (1995) Exp. Cell Res. 219(1):159-168. 3. Kuwakado K., et al. (1993) Biochem. Pharmacol. 46:1909-1916. 4. Yin D.X., and Schimke R.T. (1996) Proc. Natl. Acad. Sci. USA. 93:3394-3398.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900383-2	SIH-605-5MG	5 mg	$578		Add to Cart
BHB11900383-1	SIH-605-1MG	1 mg	$160		Add to Cart

Aphidicolin

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