Antibiotic A-23187

Mfr.No.	SIH-227
Alternative Names	5-(Methylamino)-2-({(2S,3S,8S,9R,11R)-3,9,11-trimethyl-8-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)-2-propanyl]-1,7-dioxaspiro[5.5]undec-2-yl}methyl)-1,3-benzoxazole-4-carboxylic acid, A23187, Calcimycin
Appearance	White Solid
Function	Ca2+ ionophore
Inchi	InChI=1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8
Inchikey	HIYAVKIYRIFSCZ-CVXKHCKVSA-N
Mode Of Action	Inducer
Molecular Formula	C29H37N3O6
Pubchem Cid	40486
Research Area	Cancer ; Apoptosis
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Smiles	C[C@H]1CCC2([C@@H](C[C@H]([C@H](O2)C(C)C(=O)C3=CC=CN3)C)C)O[C@H]1CC4=NC5=C(O4)C=CC(=C5C(=O)O)NC
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	52665-69-7
Molecular Weight	523.63
Scientific Background	A23187 is a mobile ion-carrier that forms stable complexes with divalent cations. It has antibiotic properties against gram positive bacteria and funghi. It also acts as divalent cation ionophore, that is used to increase intracellular calcium levels in intact cells (1). It also induces apoptosis in some cells and prevents it in others (2).
Solubility	Soluble to 10 mM in ethanol and to 50 mM in DMSO
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.01
Purity	>98%
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Abbott B.J., et al. (1979) Antimicrob Agents Chemother. 16(6): 808-812. 2. http://a23187.4mg.com

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900051-1	SIH-227-10MG	10 mg	$103		Add to Cart
BHB11900051-2	SIH-227-50MG	50 mg	$376		Add to Cart

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