(±)11(12)-EET

Mfr.No.	T35494
Description	(±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.(1)(2)(3()A higher proportion of 11(R),12(S)-EET is produced by the CYP450 isoforms CYP2C23 and CYP2C24 while CYP2B2 produces a higher proportion of 11(S),12(R)-EET.(3)11(12)-EET has been shown, along with 8(9)-EET to play a role in the recovery of depleted calcium pools in cultured smooth muscle cells(4) It also inhibits basolateral 18-pS potassium channels in the renal cortical collecting duct when used at a concentration of 100 nM.(5)11(12)-EET (50 ug/kg per day) increases adhesion of isolated peripheral blood leukocytes in a chamber coated with P-selectin and ICAM-1 but does not affect choroidal neovascularization size following laser photocoagulation(6) It also has anti-inflammatory, angiogenic, and cardioprotective properties(7)
Molecular Formula	C20H32O3
Signaling Pathways	Others
Smiles	CCCCCC=C/C(CH)1O(CH)1CC=C/CC=C/CCCC(O)=O
Cas Number	123931-40-8
Molecular Weight	320.473
Target	Others

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SKU	Supplier No.	Size	Your price	Quantity
BHB20424923	T35494	1 mg	-		Add to Quote