Mouse Anti-Human ATP7B (Copper Transporting ATPase 2) Monoclonal IgG1

Mfr.No.	SMC-399, SMC-399D, SMC-399D-A390, SMC-399D-A488, SMC-399D-A594, SMC-399D-APC, SMC-399D-BI, SMC-399D-FITC, SMC-399D-HRP, SMC-399D-PCP, SMC-399D-RPE, SMC-399S
Immunogen Species	Human
Alternative Names	ATP7B Antibody, ATPase Cu++ transporting beta polypeptide Antibody, ATPase Cu(2+) transporting beta polypeptide Antibody, Copper pump 2 Antibody, Copper transporting ATPase 2 Antibody, PWD Antibody, Toxic milk Antibody, tx Antibody, WC1 Antibody, WD Antibody, Wilson disease associated protein Antibody, WND Antibody, WND/140 kDa Antibody
Categories	Antibodies
Cellular Localization	Cytoplasm, Mitochondrion, Golgi Apparatus, Trans-Golgi Network Membrane
Certificate Of Analysis	1 ug/ml of SMC-399 was sufficient for detection of Copper-transporting ATPase2 in 20 ug of rat brain lysate by colorimetric immunoblot analysis using Goat IgG:HRP as the secondary antibody.
Clonality	Monoclonal
Description	Mouse Anti-Human Copper Transporting ATPase 2 Monoclonal IgG1
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Mouse
Gross Weight (kg)	1.4
Immunogen	Synthetic peptide amino acids 3-21 (cytoplasmic N-terminus) of human Copper-transporting ATPase2, Homo Sapiens (Human)
Immunogen Region	Synthetic peptide amino acids 3-21 (cytoplasmic N-terminus) of human Copper-transporting ATPase2
Isotype	IgG1
Launch Date	2012/06/06
Net Weight (g)	0.1
Reactivity	Rat, Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Mouse, Rat, Human

Antigen	ATP7B
Swissprot	B7ZLR4
Accession Number	NP_000044.2
Gene Id	540
Target	ATP7B
Clone No	S62-29
Research Area	Ion Channels, Cell Signaling, Neuroscience

Buffer	PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration	1 mg/ml
Dilutions	WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification	Protein G Purified
Scientific Background	The copper efflux transporters ATP7A and ATP7B sequester intracellular copper into the vesicular secretory pathway for export from the cell. ATP7b is an important protein for copper transport and elimination of excess copper from the body. ATP7b transports metals in and out of cells using ATP. There are 3 known isoforms of the ATP7b gene; A is found in the liver, kidney, and brain, the shorter form B is found in brain tissue, and the third isoform, known as WND/140 KDA is found in mitochondria. Mutations in the ATP7b gene can cause Wilson's disease, an inherited disorder causing copper poisoning in the brain and liver, characterized by neurological symptoms and hepatic damage.
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~160kDa in rat brain membrane preparations.
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	IHC, IP, WB, ICC/IF
Description	WB ; IHC ; ICC ; IF ; IP
Dilution	WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Tanzi R.E., et al. (1993) Nature Genetics. 5: 344-350. 2. Ghr/nlm.gov/gene/ATP7B

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11903488-1	SMC-399D	Unconjugated	100 ug	$337	Add to Cart
BHA11903488-2	SMC-399D-A390	ATTO 390	100 ug	$392	Add to Cart
BHA11903488-3	SMC-399D-A488	ATTO 488	100 ug	$391	Add to Cart
BHA11903488-4	SMC-399D-A594	ATTO 594	100 ug	$391	Add to Cart
BHA11903488-5	SMC-399D-APC	APC	100 ug	$390	Add to Cart
BHA11903488-6	SMC-399D-BI	Biotin	100 ug	$386	Add to Cart
BHA11903488-7	SMC-399D-FITC	FITC	100 ug	$381	Add to Cart
BHA11903488-8	SMC-399D-HRP	HRP	100 ug	$377	Add to Cart
BHA11903488-9	SMC-399D-PCP	PerCP	100 ug	$390	Add to Cart
BHA11903488-10	SMC-399D-RPE	RPE	100 ug	$388	Add to Cart
BHA11903488-11	SMC-399S	Unconjugated	12 ug	$45	Add to Cart

ATP7B Antibody, Clone L62/29 (SMC-399)

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