ELISA Kit for Rat Urocortin

Mfr.No.	E2199r
Alternative Names	Corticotensin
Categories	Elisa
Function	Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta.
Specificity	Natural and recombinant Rat Urocortin
Subcellular Location	Secreted
Detection Range	31.2-2000pg/mL
Entryname	UCN1_RAT
Method Type	Sandwich
Platform	PF00473
Protein Name	Urocortin
Sensitivity	15.77pg/mL
Sequence	50: MRQRGRATLL ; VALLLLVQLR ; PESSQWSPAA ; AAANVVQDPN ; LRWNPGVRNQ ; 100: GGGVRALLLL ; LAERFPRRAG ; SEPAGERQRR ; DDPPLSIDLT ; FHLLRTLLEL ; 122: ARTQSQRERA ; EQNRIIFDSV ; GK
Sequence Length	122
String	P55090
Sub Unit	Interacts with CRHR1 and CRHR2 (via their N-terminal extracellular domain).

Reference	1. "Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor." Vaughan J.M., Donaldson C.J., Bittencourt J., Perrin M.H., Lewis K.A., Sutton S.W., Chan R., Turnbull A., Lovejoy D., Rivier C., Rivier J.E., Sawchenko P., Vale W.W. Nature378:287-292(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION strain: Sprague-Dawley. 2. "Detection of rat urocortin in lymphoid tissues: implications for the functional assessment of urocortin as a novel neuro-immunomodulatory peptide." Park J.H., Lee Y.J., Kim K.L. Submitted (1998-09) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE strain: Lewis. 3. "Urocortin 1 reduces food intake and ghrelin secretion via CRF(2) receptors." Yakabi K., Noguchi M., Ohno S., Ro S., Onouchi T., Ochiai M., Takabayashi H., Takayama K., Harada Y., Sadakane C., Hattori T. Am. J. Physiol.301:E72-82(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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