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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Transient receptor potential cation channel subfamily V member 1

SKU : BHE13811322

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E12152r
Alternative Names	Capsaicin receptor ; Osm-9-like TRP channel 1 ; OTRPC1 ; Vanilloid receptor 1 ; Vanilloid receptor type 1-like ; Vr1 ; Vr1l
Categories	Elisa
Function	Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accubens by affecting AMPA receptors endocytosis.
Specificity	Natural and recombinant Rat Transient receptor potential cation channel subfamily V member 1
Subcellular Location	Cell junction synapse postsynaptic cell membrane Multi-pass membrane protein Cell projection dendritic spine membrane Multi-pass membrane protein Mostly, but not exclusively expressed in post-synaptic dendritic spines.
Detection Range	78-5000pg/mL
Entryname	TRPV1_RAT
Method Type	Sandwich
Platform	PF00023
Protein Name	Transient receptor potential cation channel subfamily V member 1
Sensitivity	41.4pg/mL
Sequence	50: MEQRASLDSE ; ESESPPQENS ; CLDPPDRDPN ; CKPPPVKPHI ; FTTRSRTRLF ; 100: GKGDSEEASP ; LDCPYEEGGL ; ASCPIITVSS ; VLTIQRPGDG ; PASVRPSSQD ; 150: SVSAGEKPPR ; LYDRRSIFDA ; VAQSNCQELE ; SLLPFLQRSK ; KRLTDSEFKD ; 200: PETGKTCLLK ; AMLNLHNGQN ; DTIALLLDVA ; RKTDSLKQFV ; NASYTDSYYK ; 250: GQTALHIAIE ; RRNMTLVTLL ; VENGADVQAA ; ANGDFFKKTK ; GRPGFYFGEL ; 300: PLSLAACTNQ ; LAIVKFLLQN ; SWQPADISAR ; DSVGNTVLHA ; LVEVADNTVD ; 350: NTKFVTSMYN ; EILILGAKLH ; PTLKLEEITN ; RKGLTPLALA ; ASSGKIGVLA ; 400: YILQREIHEP ; ECRHLSRKFT ; EWAYGPVHSS ; LYDLSCIDTC ; EKNSVLEVIA ; 450: YSSSETPNRH ; DMLLVEPLNR ; LLQDKWDRFV ; KRIFYFNFFV ; YCLYMIIFTA ; 500: AAYYRPVEGL ; PPYKLKNTVG ; DYFRVTGEIL ; SVSGGVYFFF ; RGIQYFLQRR ; 550: PSLKSLFVDS ; YSEILFFVQS ; LFMLVSVVLY ; FSQRKEYVAS ; MVFSLAMGWT ; 600: NMLYYTRGFQ ; QMGIYAVMIE ; KMILRDLCRF ; MFVYLVFLFG ; FSTAVVTLIE ; 650: DGKNNSLPME ; STPHKCRGSA ; CKPGNSYNSL ; YSTCLELFKF ; TIGMGDLEFT ; 700: ENYDFKAVFI ; ILLLAYVILT ; YILLLNMLIA ; LMGETVNKIA ; QESKNIWKLQ ; 750: RAITILDTEK ; SFLKCMRKAF ; RSGKLLQVGF ; TPDGKDDYRW ; CFRVDEVNWT ; 800: TWNTNVGIIN ; EDPGNCEGVK ; RTLSFSLRSG ; RVSGRNWKNF ; ALVPLLRDAS ; 838: TRDRHATQQE ; EVQLKHYTGS ; LKPEDAEVFK ; DSMVPGEK
Sequence Length	838
String	O35433
Sub Unit	Interacts with PIRT (By similarity). Self-associates. Probably homotetramer. May also form a heteromeric channel with TRPV3. Interacts with calmodulin, PRKCM and CSK. Interacts with PRKCG and NTRK1, probably by forming a trimeric complex.

Uniprot	O35433
Gene Name	Trpv1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:83810
Unigene	Rn.3073

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SKU	Supplier No.	Size	Your price	Quantity
BHE13811322	E12152r	96T	$796		Add to Cart

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