JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
orders@biohippo.com

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Solute carrier family 12 member 5

SKU : BHE13810505

Contact us to order

Tel

+1 866.986.9598

Email

orders@biohippo.com

Get a Quote

Request More Infos

EIAAB SCIENCE INC, WUHAN

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

orders@biohippo.com

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	E9328r
Alternative Names	Electroneutral potassium-chloride cotransporter 2 ; Furosemide-sensitive K-Cl cotransporter ; K-Cl cotransporter 2 ; rKCC2 ; Neuronal K-Cl cotransporter ; Kcc2
Categories	Elisa
Function	Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons. Necessary for the ontogenic change in response to gamma-aminobutyric acid (GABA) from depolarization to hyperpolarization during neuronal development.
Specificity	Natural and recombinant Rat Solute carrier family 12 member 5
Subcellular Location	Membrane Multi-pass membrane protein
Entryname	S12A5_RAT
Platform	PF00324
Protein Name	Solute carrier family 12 member 5
Sequence	50: MSRRFTVTSL ; PPAASAASAD ; PESRRHSVAD ; PRRLPREDVK ; GDGNPKESSP ; 100: FINSTDTEKG ; REYDGRNMAL ; FEEEMDTSPM ; VSSLLSGLAN ; YTNLPQGSKE ; 150: HEEAENNEGG ; KKKPVQAPRM ; GTFMGVYLPC ; LQNIFGVILF ; LRLTWVVGIA ; 200: GIMESFCMVF ; ICCSCTMLTA ; ISMSAIATNG ; VVPAGGSYYM ; ISRSLGPEFG ; 250: GAVGLCFYLG ; TTFAGAMYIL ; GTIEILLAYL ; FPAMAIFKAE ; DASGEAAAML ; 300: NNMRVYGTCV ; LTCMATVVFV ; GVKYVNKFAL ; VFLGCVILSI ; LAIYAGVIKS ; 350: AFDPPNFPIC ; LLGNRTLSRH ; GFDVCAKLAW ; EGNETVTTRL ; WGLFCSSRLL ; 400: NATCDEYFTR ; NNVTEIQGIP ; GAASGLIKEN ; LWSSYLTKGV ; IVERRGMPSV ; 450: GLADGTPVDM ; DHPYVFSDMT ; SYFTLLVGIY ; FPSVTGIMAG ; SNRSGDLRDA ; 500: QKSIPTGTIL ; AIATTSAVYI ; SSVVLFGACI ; EGVVLRDKFG ; EAVNGNLVVG ; 550: TLAWPSPWVI ; VIGSFFSTCG ; AGLQSLTGAP ; RLLQAISRDG ; IVPFLQVFGH ; 600: GKANGEPTWA ; LLLTACICEI ; GILIASLDEV ; APILSMFFLM ; CYMFVNLACA ; 650: VQTLLRTPNW ; RPRFRYYHWT ; LSFLGMSLCL ; ALMFICSWYY ; ALVAMLIAGL ; 700: IYKYIEYRGA ; EKEWGDGIRG ; LSLSAARYAL ; LRLEEGPPHT ; KNWRPQLLVL ; 750: VRVDQDQNVV ; HPQLLSLTSQ ; LKAGKGLTIV ; GSVLEGTFLD ; NHPQAQRAEE ; 800: SIRRLMEAEK ; VKGFCQVVIS ; SNLRDGVSHL ; IQSGGLGGLQ ; HNTVLVGWPR ; 850: NWRQKEDHQT ; WRNFIELVRE ; TTAGHLALLV ; TKNVSMFPGN ; PERFSEGSID ; 900: VWWIVHDGGM ; LMLLPFLLRH ; HKVWRKCKMR ; IFTVAQMDDN ; SIQMKKDLTT ; 950: FLYHLRITAE ; VEVVEMHESD ; ISAYTYEKTL ; VMEQRSQILK ; QMHLTKNERE ; 1000: REIQSITDES ; RGSIRRKNPA ; NTRLRLNVPE ; ETACDNEEKP ; EEEVQLIHDQ ; 1050: SAPSCPSSSP ; SPGEEPEGEG ; ETDPEKVHLT ; WTKDKSAAQK ; NKGPSPVSSE ; 1100: GIKDFFSMKP ; EWENLNQSNV ; RRMHTAVRLN ; EVIVNKSRDA ; KLVLLNMPGP ; 1139: PRNRNGDENY ; MEFLEVLTEQ ; LDRVMLVRGG ; GREVITIYS
Sequence Length	1139
String	Q63633
Sub Unit	Homomultimer and heteromultimer with other K-Cl cotransporters. Interacts with AP2A1.

Uniprot	Q63633
Gene Name	Slc12a5
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:171373
Unigene	Rn.10513

Reference	1. "Molecular characterization of a putative K-Cl cotransporter in rat brain. A neuronal-specific isoform." Payne J.A., Stevenson T.J., Donaldson L.F. J. Biol. Chem.271:16245-16252(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2) strain: Sprague-Dawley. tissue: Brain. 2. "A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2." Uvarov P., Ludwig A., Markkanen M., Pruunsild P., Kaila K., Delpire E., Timmusk T., Rivera C., Airaksinen M.S. J. Biol. Chem.282:30570-30576(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) strain: Wistar. tissue: Hippocampus. 3. "The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation." Rivera C., Voipio J., Payne J.A., Ruusuvuori E., Lahtinen H., Lamsa K., Pirvola U., Saarma M., Kaila K. Nature397:251-255(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 4. "A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity." Casula S., Shmukler B.E., Wilhelm S., Stuart-Tilley A.K., Su W., Chernova M.N., Brugnara C., Alper S.L. J. Biol. Chem.276:41870-41878(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHE13810505	E9328r	96T	$796		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.