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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Runt-related transcription factor 2

SKU : BHE13810696

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9029r
Alternative Names	Core-binding factor subunit alpha-1 ; CBF-alpha-1 ; Osteoblast-specific transcription factor 2 ; OSF-2 ; Cbfa1 ; Osf2
Categories	Elisa
Function	Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).
Specificity	Natural and recombinant Rat Runt-related transcription factor 2
Subcellular Location	Nucleus
Detection Range	0.625-40ng/mL
Entryname	RUNX2_RAT
Method Type	Sandwich
Platform	PF00853
Protein Name	Runt-related transcription factor 2
Sensitivity	0.321ng/mL
Sequence	50: MLHSPHKQPQ ; NHKCGANFLQ ; EDSKEALVFK ; WLISAGHYQP ; PRPTESVSAL ; 100: STVHAVIFKA ; ASSIYNRGHK ; FYLEKKGGTM ; ASNSLFSAVT ; PCQQSFFWNK ; 150: TLPVAFKVVA ; LGEVPDGTVV ; TVMAGNDENY ; SAELRNASAV ; MKNQVARFND ; 200: LRFVGRSGRG ; KSFTLTITVF ; TNPPQVATYH ; RAIKVTVDGP ; REPRRHRQKL ; 218: DDSKPSLFSD ; RLSDLGRI
Sequence Length	218
String	Q9Z2J9
Sub Unit	Interaction with SATB2 results in enhanced DNA binding and transactivation by these transcription factors (By similarity). Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with XRCC6 (Ku70) and XRCC5 (Ku80). Interacts with KAT6A and KAT6B. Interacts with HIVEP3 and HIPK3.

Uniprot	Q9Z2J9
Gene Name	Runx2
Immunogen Species	Rattus norvegicus (Rat)
Unigene	Rn.214214

Reference	1. "Genomic structure and isoform expression of the mouse, rat and human Cbfa1/Osf2 transcription factor." Xiao Z.S., Thomas R., Hinson T.K., Quarles L.D. Gene214:187-197(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-98 2. "Regulatory expression of rat CBFA1 in osteoblastic cells." Goseki M.S., Iimura T. Submitted (1999-04) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 99-218 tissue: Osteoblast.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810696	E9029r	96T	$796		Add to Cart

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