Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.
Specificity
Natural and recombinant Rat Regulator of G-protein signaling 2
"PTH induced RGS cDNA sequence in rat osteoblast-like UMR106 cell." Ko J.K., Kim I.S., Park D.H. Submitted (2001-07) to the EMBL/GenBank/DDBJ databases
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