Acts together with cubilin to mediate HDL endocytosis (By similarity). Receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B.
Specificity
Natural and recombinant Rat Low-density lipoprotein receptor-related protein 2
Subcellular Location
Cell membrane Single-pass type I membrane protein Membrane clathrin-coated pit Cytoplasm Expressed in clathrin-coated pits, a soluble form is possibly derived by cleavage at the cell surface.
Binds plasminogen, extracellular matrix components, plasminogen activator-plasminogen activator inhibitor type I complex, apolipoprotein E-enriched beta-VLDL, lipoprotein lipase, lactoferrin, CLU/clusterin and calcium. Forms a multimeric complex together with a receptor-associated protein (RAP). Binds to ankyrin-repeat family A protein 2 (ANKRA2). Interacts with LRP2BP.
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Reviews of ELISA Kit for Rat Low-density lipoprotein receptor-related protein 2