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ELISA Kit for Rat Kalirin

SKU : BHE13806293

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E14464r
Alternative Names	Huntingtin-associated protein-interacting protein ; PAM COOH-terminal interactor protein 10 ; P-CIP10 ; Protein Duo ; Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain ; Duo ; Hapip
Categories	Elisa
Function	Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Isoforms 1 and 7 are necessary for neuronal development and axonal outgrowth. Isoform 6 is required for dendritic spine formation.
Specificity	Natural and recombinant Rat Kalirin
Subcellular Location	Cytoplasm Cytoplasm cytoskeleton Isoform 6 is largely associated with synaptosomal membranes and to punctate structures in cortical neurons. Isoforms 1 and 7 are expressed in neuronal cell bodies, isoform 7 is also found in neuronal processes.
Entryname	KALRN_RAT
Platform	PF00041
Protein Name	Kalirin
Sequence	50: MVLSGSFRND ; GLKASDVLPI ; LKEKVAFVSG ; GRDKRGGPIL ; TFPARTNHDR ; 100: IRQEDLRKLV ; TNLASVPSED ; VCKRGFTVII ; DMRGSKWDLI ; KPLLKTLQEA ; 150: FPAEIHVALI ; IKPDNFWQKQ ; KTNFGSSKFI ; FETSMVSVEG ; LTKLVDPSQL ; 200: TEEFDGSLDY ; NHEEWIELRL ; SLEEFFNSAV ; HLLSRLEDLQ ; EMLARKEFPV ; 250: DVEGSRRLID ; EHTQLKKKVL ; KAPVEELDRE ; GQRLLQCIRC ; SDGFSGRNCI ; 300: PGSADFQSLV ; PKITSLLDKL ; HSTRQHLHQM ; WHVRKLKLDQ ; CFQLRLFEQD ; 350: AEKMFDWISH ; NKELFLQSHT ; EIGVSYQHAL ; DLQTQHNHFA ; MNSMNAYVNI ; 400: NRIMSVASRL ; SEAGHYASQQ ; IKQISTQLDQ ; EWKSFAAALD ; ERSTILAMSA ; 450: VFHQKAEQFL ; SGVDAWCKMC ; SEGGLPSEMQ ; DLELAIHHHQ ; SLYEQVTQAY ; 500: TEVSQDGKAL ; LDVLQRPLSP ; GNSESLTATA ; NYSKAVHQVL ; DVVHEVLHHQ ; 550: RRLESIWQHR ; KVRLHQRLQL ; CVFQQDVQQV ; LDWIENHGEA ; FLSKHTGVGK ; 600: SLHRARALQK ; RHDDFEEVAQ ; NTYTNADKLL ; EAAEQLAQTG ; ECDPEEIYKA ; 650: ARHLEVRIQD ; FVRRVEQRKL ; LLDMSVSFHT ; HTKELWTWME ; DLQKEVLEDV ; 700: CADSVDAVQE ; LIKQFQQQQT ; ATLDATLNVI ; KEGEDLIQQL ; RSAPPSLGEP ; 750: TEARDSAVSN ; NKTPHSSSIS ; HIESVLQQLD ; DAQVQMEELF ; HERKIKLDIF ; 800: LQLRIFEQYT ; IEVTAELDAW ; NEDLLRQMND ; FNTEDLTLAE ; QRLQRHTERK ; 850: LAMNNMTFEV ; IQQGQDLHQY ; IMEVQASGIE ; LICEKDVDLA ; AQVQELLEFL ; 900: HEKQHELELN ; AEQTHKRLEQ ; CLQLRHLQAE ; VKQVLGWIRN ; GESMLNASLV ; 950: NASSLSEAEQ ; LQREHEQFQL ; AIEKTHQSAL ; QVQQKAEALL ; QAGHYDADAI ; 1000: RECAEKVALH ; WQQLMLKMED ; RLKLVNASVA ; FYKTSEQVCS ; VLESLEQEYR ; 1050: RDEDWCGGRD ; KLGPAAEMDH ; VIPLLSKHLE ; QKEAFLKACT ; LARRNAEVFL ; 1100: KYIHRNNVSM ; PSVASHTRGP ; EQQVKAILSE ; LLQRENRVLH ; FWTLKKRRLD ; 1150: QCQQYVVFER ; SAKQALDWIQ ; ETGEYYLSTH ; TSTGETTEET ; QELLKEYGEF ; 1200: RVPAKQTKEK ; VKLLIQLADS ; FVEKGHIHAT ; EIRKWVTTVD ; KHYRDFSLRM ; 1250: GKYRYTLEKA ; LGVNTEDNKD ; LELDIIPASL ; SDREVKLRDA ; NHEVNEEKRK ; 1300: SARKKEFIMA ; ELLQTEKAYV ; RDLHECLETY ; LWEMTSGVEE ; IPPGILNKEH ; 1350: IIFGNIQEIY ; DFHNNIFLKE ; LEKYEQLPED ; VGHCFVTWAD ; KFQMYVTYCK ; 1400: NKPDSNQLIL ; EHAGTFFDEI ; QQRHGLANSI ; SSYLIKPVQR ; VTKYQLLLKE ; 1450: LLTCCEEGKG ; ELKDGLEVML ; SVPKKANDAM ; HVSMLEGFDE ; NLDVQGELIL ; 1500: QDAFQVWDPK ; SLIRKGRERH ; LFLFEISLVF ; SKEIKDSSGH ; TKYVYKNKLL ; 1550: TSELGVTEHV ; EGDPCKFALW ; SGRTPSSDNK ; TVLKASNIET ; KQEWIKNIRE ; 1600: VIQERIIHLK ; GALKEPIQLP ; KTPAKLRNNS ; KRDGVEDGDS ; QGDGSSQPDT ; 1650: ISIASRTSQN ; TVESDKLSGG ; CELTVVLQDF ; SAAHSSELSI ; QVGQTVELLE ; 1700: RPSERPGWCL ; VRTTERSPPQ ; EGLVPSSTLC ; ISHSRSSVEM ; DCFFPLVKDS ; 1750: YSHSSGENGG ; KSESVANLQS ; QPSLNSIHSS ; PGPKRSTNTL ; KKWLTSPVRR ; 1800: LNSGKADGNI ; KKQKKVRDGR ; KSFDLGSPKP ; GDETTPQGDS ; ADEKSKKGWG ; 1850: EDEPDEESHT ; PLPPPMKIFD ; NDPTQDEMSS ; LLAARQAPTD ; VPTAADLVSA ; 1900: IEKLVKSKLT ; LEGGSYRGSL ; KDPTVCLNEG ; MAPPTPPRNL ; EEEQKAKALR ; 1950: GRMFVLNELV ; QTEKDYVKDL ; GIVVEGFMKR ; IEEKGVPEDM ; RGKEKIVFGN ; 2000: IHQIYDWHKD ; FFLAELEKCI ; QEQDRLAQLF ; IKHERKLHIY ; VWYCQNKPRS ; 2050: EYIVAEYDAY ; FEEVKQEINQ ; RLTLSDFLIK ; PIQRITKYQL ; LLKDFLRYSE ; 2100: KAGLECSDIE ; KAVELMCLVP ; KRCNDMMNLG ; RLQGFEGTLT ; AQGKLLQQDT ; 2150: FYVIELDAGM ; QSRTKERRVF ; LFEQIVIFSE ; LLRKGSLTPG ; YMFKRSIKMN ; 2200: YLVLEEDVDD ; DPCKFALMNR ; ETSERVILQA ; ANSDIQQAWV ; QDINQVLETQ ; 2250: RDFLNALQSP ; IEYQRKERST ; AVIRSQPPRV ; PQASPRPYSS ; VPVGSEKPPK ; 2300: GSSYNPPLPP ; LKISTSNGSP ; GFDYHQPGDK ; FDASKQNDLG ; GCNGTSTMAV ; 2350: IKDYYALKEN ; EICVSQGEVV ; QVLAVNQQNM ; CLVYQPASDH ; SPAAEGWVPG ; 2400: SILAPLTKAT ; APAESSDESI ; KKSCSWHTLR ; MRKRADVENT ; GKNEATGPRK ; 2450: PKDILGNKAS ; VKETNSSEES ; ECDDLDPNTS ; MEILNPNFIQ ; EVAPEFLVPL ; 2500: VDVTCLLGDT ; VLLQCKACGR ; PKPTITWKGP ; DQNILDTDNS ; SATYTISSCD ; 2550: SGESTLKICN ; LMPQDSGIYT ; CIATNDHGTA ; STSATVKVQG ; VPAAPNRPIA ; 2600: QERSCTSVIL ; RWLPPASTGN ; CTISGYTVEY ; REEGSQVWQQ ; SVASTLDTYL ; 2650: VIEDLSPGCP ; YQFRVSASNP ; WGISLPSEPS ; EFVHLPEYDA ; AADGATISWK ; 2700: ENFDSAYTEL ; NEIGRGRFSI ; VKKCIHKATR ; KDVAVKFVSK ; KMKKKEQAAH ; 2750: EAALLQHLQH ; PQYVTLHDTY ; ESPTSYILIL ; ELMDDGRLLD ; YLMNHDELME ; 2800: EKVAFYIRDI ; MEALQYLHNC ; RVAHLDIKPE ; NLLIDLRIPV ; PRVKLIDLED ; 2850: AVQISGHFHI ; HHLLGNPEFA ; APEVIQGIPV ; SLGTDIWSIG ; VLTYVMLSGV ; 2900: SPFLDESKEE ; TCINVCRVDF ; SFPHEYFCGV ; SNAARDFINV ; ILQEDFRRRP ; 2950: TAATCLQHPW ; LQPHNGSYSK ; IPLDTSRLAC ; FIERRKHQND ; VRPIPNVKSY ; 2959: IVNRVNQGT
Sequence Length	2959
String	P97924
Sub Unit	Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1). Interacts with FASLG.

Uniprot	P97924
Gene Name	Kalrn
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:84009
Unigene	Rn.87882

Reference	1. "Novel proteins that interact with the COOH-terminal cytosolic routing determinants of an integral membrane peptide-processing enzyme." Alam M.R., Caldwell B.D., Johnson R.C., Darlington D.N., Mains R.E., Eipper B.A. J. Biol. Chem.271:28636-28640(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2) tissue: Hippocampus. 2. "Kalirin, a cytosolic protein with spectrin-like and GDP/GTP exchange factor-like domains that interacts with peptidylglycine alpha-amidating monooxygenase, an integral membrane peptide-processing enzyme." Alam M.R., Johnson R.C., Darlington D.N., Hand T.A., Mains R.E., Eipper B.A. J. Biol. Chem.272:12667-12675(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3);INTERACTION WITH PAM tissue: Hippocampus. 3. "An isoform of kalirin, a brain-specific GDP/GTP exchange factor, is enriched in the postsynaptic density fraction." Penzes P., Johnson R.C., Alam M.R., Kambampati V., Mains R.E., Eipper B.A. J. Biol. Chem.275:6395-6403(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6);FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY 4. "Isoforms of kalirin, a neuronal Dbl family member, generated through use of different 5'- and 3'-ends along with an internal translational initiation site." Johnson R.C., Penzes P., Eipper B.A., Mains R.E. J. Biol. Chem.275:19324-19333(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 5 AND 7);ALTERNATIVE INITIATION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY 5. "Induction of lamellipodia by Kalirin does not require its guanine nucleotide exchange factor activity." Schiller M.R., Blangy A., Huang J., Mains R.E., Eipper B.A. Exp. Cell Res.307:402-417(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8);FUNCTION 6. "Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain." Colomer V., Engelender S., Sharp A.H., Duan K., Cooper J.K., Lanahan A., Lyford G., Worley P., Ross C.A. Hum. Mol. Genet.6:1519-1525(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 638-1216 (ISOFORM 4) tissue: Brain cortex. tissue: Hippocampus. 7. "Distinct roles for the two Rho GDP/GTP exchange factor domains of kalirin in regulation of neurite growth and neuronal morphology." Penzes P., Johnson R.C., Kambampati V., Mains R.E., Eipper B.A. J. Neurosci.21:8426-8434(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DOMAIN;DEVELOPMENTAL STAGE 8. "Regulation of RhoGEF activity by intramolecular and intermolecular SH3 domain interactions." Schiller M.R., Chakrabarti K., King G.F., Schiller N.I., Eipper B.A., Maciejewski M.W. J. Biol. Chem.281:18774-18786(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1617-1707;DOMAIN;INTERACTION WITH CRK1

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