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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat High affinity immunoglobulin epsilon receptor subunit beta

SKU : BHE13803598

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1891r
Alternative Names	Fc epsilon receptor I beta-chain ; IgE Fc receptor subunit beta ; Membrane-spanning 4-domains subfamily A member 2 ; Fce1b ; Fcer1b
Categories	Elisa
Function	High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.
Specificity	Natural and recombinant Rat High affinity immunoglobulin epsilon receptor subunit beta
Subcellular Location	Membrane Multi-pass membrane protein
Detection Range	78-5000pg/ml
Entryname	FCERB_RAT
Method Type	Sandwich
Platform	PF04103
Protein Name	High affinity immunoglobulin epsilon receptor subunit beta
Sensitivity	41.5pg/mL
Sequence	50: MDTENKSRAD ; LALPNPQESP ; SAPDIELLEA ; SPPAKALPEK ; PASPPPQQTW ; 100: QSFLKKELEF ; LGVTQVLVGL ; ICLCFGTVVC ; STLQTSDFDD ; EVLLLYRAGY ; 150: PFWGAVLFVL ; SGFLSIMSER ; KNTLYLVRGS ; LGANIVSSIA ; AGLGIAILIL ; 200: NLSNNSAYMN ; YCKDITEDDG ; CFVTSFITEL ; VLMLLFLTIL ; AFCSAVLLII ; 243: YRIGQEFERS ; KVPDDRLYEE ; LHVYSPIYSA ; LEDTREASAP ; VVS
Sequence Length	243
String	P13386
Sub Unit	Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Binds LILRB1. Interacts with FES/FPS (By similarity). Interacts with FGR.

Uniprot	P13386
Gene Name	Ms4a2
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:25316
Unigene	Rn.10922

Reference	1. "Isolation and characterization of cDNAs coding for the beta subunit of the high-affinity receptor for immunoglobulin E." Kinet J.-P., Blank U., Ra C., White K., Metzger H., Kochan J. Proc. Natl. Acad. Sci. U.S.A.85:6483-6487(1988) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 11-29; 37-43 AND 217-243 2. "The Src family kinase Fgr is critical for activation of mast cells and IgE-mediated anaphylaxis in mice." Lee J.H., Kim J.W., Kim do K., Kim H.S., Park H.J., Park D.K., Kim A.R., Kim B., Beaven M.A., Park K.L., Kim Y.M., Choi W.S. J. Immunol.187:1807-1815(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FGR;SUBCELLULAR LOCATION

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SKU	Supplier No.	Size	Your price	Quantity
BHE13803598	E1891r	96T	$796		Add to Cart

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