Muscle-specific RING finger protein 1 ; MuRF-1 ; RING-type E3 ubiquitin transferase TRIM63 ; Tripartite motif-containing protein 63 ; Murf1
Categories
Elisa
Function
E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.
Specificity
Natural and recombinant Rat E3 ubiquitin-protein ligase TRIM63
Subcellular Location
Cytoplasm Nucleus Localizes to the M- and Z-lines in skeletal muscle. Colocalizes with TNNI3 in myocytes.
Homooligomer and heterooligomer. Interacts with SUMO2, titin/TTN and GMEB1. Interacts with TRIM54 and probably with TRIM55 and TNNI3. Forms a ternary complex with GNB2L1 and PRKCE.
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