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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat CD2-associated protein

SKU : BHE13801809

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2545r
Categories	Elisa
Function	Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis.
Specificity	Natural and recombinant Rat CD2-associated protein
Subcellular Location	Cytoplasm Cytoskeleton Cell projection Ruffle Colocalizes with F-actin and BCAR1/p130Cas in membrane ruffles. Located at podocyte slit diaphragm between podocyte foot processes (By similarity). During late anaphase and telophase, concentrates in the vicinity of the midzone microtubules and in the midbody in late telophase.
Detection Range	15.6-1000pg/Ml
Entryname	CD2AP_RAT
Method Type	Sandwich
Platform	PF00018
Protein Name	CD2-associated protein
Sensitivity	7.8pg/mL
Sequence	50: MVDYIVEYDY ; DAVHDDELTI ; RVGEIIRNVK ; KLQEEGWLEG ; ELNGRRGMFP ; 100: DNFVKEIKRE ; TEPKDDNLPI ; KRERPGNVAS ; LVQRISTYGL ; PAGGIQPHPQ ; 150: TKAMKKKTKK ; RQCKVLFEYS ; PQNEDELELT ; VGDVIDVIEE ; VEEGWWSGTL ; 200: NNKLGLFPSN ; FVKELESTDD ; GEMHDAQEES ; EVSLTGPTSP ; MPSPGNGSEP ; 250: APGSVTQPKK ; IRGVGFGDIF ; KEGSVKLRTR ; TSSSETEEKK ; SEKPLILQSL ; 300: GSRTQNVEVT ; KPDIDGKIKA ; KEYCKTVFPY ; TGTNEDELTF ; REGEIIHLIS ; 350: KETGEAGWWK ; GELNGKEGVF ; PDNFAVQISE ; LDKDFPKPKK ; PPPPAKGPAP ; 400: KPDPLAGEKK ; TFPLKAEDRD ; EKSLLEQKPS ; KPAAPQVPPK ; KPTPPTKANN ; 450: LLRSPGTMYP ; KRPEKPVPPP ; PPTAKINGEV ; STISSKIDTE ; PLSKPKLDPE ; 500: QLPVRPKSVD ; LDALVARNSK ; ETDNVNFDDI ; ASSENLLHLT ; ANRPKMPGRR ; 550: LPGRFNGGHS ; PTQSPEKTLK ; LPKDDDSGNI ; KPSEFKKDAG ; YSSKPSLSAP ; 600: SSASKVNTAA ; FLSPLELKAK ; VEADDGKKSS ; LDELRAQIIE ; LLCIVDALKK ; 637: DHGKELEKLR ; RELEEEKAMR ; SNLEVEIAKL ; KKAVLLS
Sequence Length	637
Sub Unit	Self-associates. Homodimer (Potential). Interacts with F-actin, PKD2, NPHS1 and NPHS2. Interacts with WTIP. Interacts with DDN; interaction is direct. Interacts (via SH3 2 domain) with CBL (via phosphorylated C-terminus). Interacts with BCAR1/p130Cas (via SH3 domain). Interacts with MVB12A and ARHGAP17. Interacts with ANLN, CD2 and CBLB. Interacts with PDCD6IP and TSG101. Interacts with RIN3. Interacts directly with RET (inactive) and CBLC; upon RET activation by GDNF suggested to dissociate from RET as CBLC:CD2AP complex.

Uniprot	F1LRS8
Gene Name	Cd2ap
Immunogen Species	Rattus norvegicus (Rat)
Unigene	Rn.212220

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SKU	Supplier No.	Size	Your price	Quantity
BHE13801809	E2545r	96T	$796		Add to Cart

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