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ELISA Kit for Rat Advanced glycosylation end product-specific receptor

SKU : BHE13808400

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1956r
Alternative Names	Receptor for advanced glycosylation end products ; Rage
Categories	Elisa
Function	Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space (By similarity). Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.
Specificity	Natural and recombinant Rat Advanced glycosylation end product-specific receptor
Subcellular Location	Membrane Single-pass type I membrane protein
Detection Range	78-5000pg/mL
Entryname	RAGE_RAT
Method Type	Sandwich
Platform	PF08205
Protein Name	Advanced glycosylation end product-specific receptor
Sensitivity	41pg/mL
Sequence	50: MPTGTVARAW ; VLVLALWGAV ; AGGQNITARI ; GEPLMLSCKG ; APKKPTQKLE ; 100: WKLNTGRTEA ; WKVLSPQGDP ; WDSVARILPN ; GSLLLPAIGI ; VDEGTFRCRA ; 150: TNRLGKEVKS ; NYRVRVYQIP ; GKPEIVNPAS ; ELTANVPNKV ; GTCVSEGSYP ; 200: AGTLSWHLDG ; KPLIPDGKGT ; VVKEETRRHP ; ETGLFTLRSE ; LTVTPAQGGT ; 250: TPTYSCSFSL ; GLPRRRPLNT ; APIQPRVREP ; LPPEGIQLLV ; EPEGGTVAPG ; 300: GTVTLTCAIS ; AQPPPQIHWI ; KDGTPLPLAP ; SPVLLLPEVG ; HEDEGIYSCV ; 350: ATHPSHGPQE ; SPPVNIRVTE ; TGDEGQAAGS ; VDGSGLGTLA ; LALGILGGLG ; 400: IAALLIGAIL ; WRKRQPRLEE ; RKAPESQEDE ; EERAELNQSE ; EAEMPENGAG ; 402: GP
Sequence Length	402
String	Q63495
Sub Unit	Interacts with S100A12 and APP (By similarity). Interacts with S100B and S100A1.

Uniprot	Q63495
Gene Name	Ager
Immunogen Species	Rattus norvegicus (Rat)
Unigene	Rn.9829

Reference	1. "Recombinant advanced glycation end product receptor pharmacokinetics in normal and diabetic rats." Renard C., Chappey O., Wautier M.P., Nagashima M., Lundh E., Morser J., Zhao L., Schmidt A.M., Scherrmann J.M., Wautier J.-L. Mol. Pharmacol.52:54-62(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Sprague-Dawley. tissue: Lung. 2. "S100B interaction with the receptor for advanced glycation end products (RAGE): a novel receptor-mediated mechanism for myocyte apoptosis postinfarction." Tsoporis J.N., Izhar S., Leong-Poi H., Desjardins J.F., Huttunen H.J., Parker T.G. Circ. Res.106:93-101(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH S100B AND S100A1;INDUCTION;TISSUE SPECIFICITY

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808400	E1956r	96T	$796		Add to Cart

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