Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor.
Specificity
Natural and recombinant Rat Adenylate cyclase type 10
Subcellular Location
Cell membrane Peripheral membrane protein Cytoplasmic side Cytoplasm cytoskeleton Mitochondrion Cytoplasm perinuclear region Cytoplasm cytoskeleton centrosome centriole Distributed to subcellular compartments containing cAMP targets. Found as a plasma membrane-associated protein, protein concentrated in the perinuclear region and protein colocalized with actin, tubulin or centriole.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 60-67; 254-262 AND 402-409;BIOPHYSICOCHEMICAL PROPERTIES;TISSUE SPECIFICITY;SUBCELLULAR LOCATION