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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Spastin

SKU : BHE13810787

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15329m
Alternative Names	Kiaa1083 ; Spg4
Categories	Elisa
Function	ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis (By similarity). Required for development of axonal processes and for axonal branching.
Specificity	Natural and recombinant Mouse Spastin
Subcellular Location	Membrane Single-pass membrane protein Cytoplasm cytoskeleton centrosome Cytoplasm cytoskeleton Cytoplasm perinuclear region Endoplasmic reticulum Endosome Nucleus Cytoplasm cytoskeleton spindle Localization to the centrosome is independent of microtubules. Localizes to the midbody of dividing cells, and this requires CHMP1B (By similarity). Evenly distributed along early axons and concentrates in the growth cone of the axons of late stage 3 neurons.
Entryname	SPAST_MOUSE
Platform	PF00004
Protein Name	Spastin
Sequence	50: MSSPAGRRKK ; KGSGGASPAP ; ARPPPPAAVP ; APAAGPAPAA ; GSPPKRNPSS ; 100: FSSPLVVGFA ; LLRLLACHLG ; LLFAWLCQRF ; SRALMAAKRS ; SGTAPAPASP ; 150: SPPEPGPGGE ; AESVRVFHKQ ; AFEYISIALR ; IDEEEKAGQK ; EQAVEWYKKG ; 200: IEELEKGIAV ; IVTGQGEQYE ; RARRLQAKMM ; TNLVMAKDRL ; QLLEKLQPVL ; 250: QFSKSQTDVY ; NESTNLTCRN ; GHLQSESGAV ; PKRKDPLTHA ; SNSLPRSKTV ; 300: LKSGSAGLSG ; HHRAPSCSGL ; SMVSGARPGP ; GPAATTHKGT ; PKPNRTNKPS ; 350: TPTTAVRKKK ; DLKNFRNVDS ; NLANLIMNEI ; VDNGTAVKFD ; DIAGQELAKQ ; 400: ALQEIVILPS ; LRPELFTGLR ; APARGLLLFG ; PPGNGKTMLA ; KAVAAESNAT ; 450: FFNISAASLT ; SKYVGEGEKL ; VRALFAVARE ; LQPSIIFIDE ; VDSLLCERRE ; 500: GEHDASRRLK ; TEFLIEFDGV ; QSAGDDRVLV ; MGATNRPQEL ; DEAVLRRFIK ; 550: RVYVSLPNEE ; TRLLLLKNLL ; CKQGSPLTQK ; ELAQLARMTD ; GYSGSDLTAL ; 600: AKDAALGPIR ; ELKPEQVKNM ; SASEMRNIRL ; SDFTESLKKI ; KRSVSPQTLE ; 614: AYIRWNKDFG ; DTTV
Sequence Length	614
String	Q9QYY8
Sub Unit	Homohexamer. The homohexamer is stabilized by ATP-binding. The homohexamer may adopt a ring conformation through which microtubules pass prior to being severed. Binds to microtubules at least in part via the alpha-tubulin and beta-tubulin tails. Interacts (via MIT domain) with CHMP1B; the interaction is direct. Interacts with ATL1, RTN1, SSNA1 and ZFYVE27.

Uniprot	Q9QYY8
Gene Name	Spast
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:50850
Unigene	Mm.19804

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810787	E15329m	96T	$776		Add to Cart

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