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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Signal transducer and activator of transcription 5A

SKU : BHE13810761

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1738m
Alternative Names	Mammary gland factor ; Mgf ; Mpf
Categories	Elisa
Function	Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription.
Specificity	Natural and recombinant Mouse Signal transducer and activator of transcription 5A
Subcellular Location	Cytoplasm Nucleus Translocated into the nucleus in response to phosphorylation.
Detection Range	31.2-2000pg/mL
Entryname	STA5A_MOUSE
Method Type	Sandwich
Platform	PF00017
Protein Name	Signal transducer and activator of transcription 5A
Sensitivity	15.6pg/mL
Sequence	50: MAGWIQAQQL ; QGDALRQMQV ; LYGQHFPIEV ; RHYLAQWIES ; QPWDAIDLDN ; 100: PQDRGQATQL ; LEGLVQELQK ; KAEHQVGEDG ; FLLKIKLGHY ; ATQLQNTYDR ; 150: CPMELVRCIR ; HILYNEQRLV ; REANNCSSPA ; GVLVDAMSQK ; HLQINQRFEE ; 200: LRLITQDTEN ; ELKKLQQTQE ; YFIIQYQESL ; RIQAQFAQLG ; QLNPQERMSR ; 250: ETALQQKQVS ; LETWLQREAQ ; TLQQYRVELA ; EKHQKTLQLL ; RKQQTIILDD ; 300: ELIQWKRRQQ ; LAGNGGPPEG ; SLDVLQSWCE ; KLAEIIWQNR ; QQIRRAEHLC ; 350: QQLPIPGPVE ; EMLAEVNATI ; TDIISALVTS ; TFIIEKQPPQ ; VLKTQTKFAA ; 400: TVRLLVGGKL ; NVHMNPPQVK ; ATIISEQQAK ; SLLKNENTRN ; ECSGEILNNC ; 450: CVMEYHQATG ; TLSAHFRNMS ; LKRIKRADRR ; GAESVTEEKF ; TVLFESQFSV ; 500: GSNELVFQVK ; TLSLPVVVIV ; HGSQDHNATA ; TVLWDNAFAE ; PGRVPFAVPD ; 550: KVLWPQLCEA ; LNMKFKAEVQ ; SNRGLTKENL ; VFLAQKLFNI ; SSNHLEDYNS ; 600: MSVSWSQFNR ; ENLPGWNYTF ; WQWFDGVMEV ; LKKHHKPHWN ; DGAILGFVNK ; 650: QQAHDLLINK ; PDGTFLLRFS ; DSEIGGITIA ; WKFDSPDRNL ; WNLKPFTTRD ; 700: FSIRSLADRL ; GDLNYLIYVF ; PDRPKDEVFA ; KYYTPVLAKA ; VDGYVKPQIK ; 750: QVVPEFVNAS ; TDAGASATYM ; DQAPSPVVCP ; QPHYNMYPPN ; PDPVLDQDGE ; 793: FDLDESMDVA ; RHVEELLRRP ; MDSLDARLSP ; PAGLFTSARS ; SLS
Sequence Length	793
String	P42230
Sub Unit	Forms a homodimer or a heterodimer with a related family member. Interacts with NCOA1 and SOCS7 (By similarity). Binds NR3C1.

Uniprot	P42230
Gene Name	Stat5a
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:20850
Unigene	Mm.277403

Reference	1. "Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs." Mui A.L.-F., Wakao H., O'Farrell A.-M., Harada N., Miyajima A. EMBO J.14:1166-1175(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: C57BL/6 X A/J. tissue: Liver. 2. "Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue." Liu X., Robinson G.W., Gouilleux F., Groner B., Hennighausen L. Proc. Natl. Acad. Sci. U.S.A.92:8831-8835(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: C57BL/6. 3. Zhou L.X., Moore R.C., Oka T. Submitted (1995-09) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: C3H/HeN. tissue: Mammary gland. 4. "Characterization of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocortiocoid receptor in mammary cells." Cella N., Groner B., Hynes N.E. Mol. Cell. Biol.18:1783-1792(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NR3C1 5. "ErbB4 signaling in the mammary gland is required for lobuloalveolar development and Stat5 activation during lactation." Jones F.E., Welte T., Fu X.Y., Stern D.F. J. Cell Biol.147:77-88(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ERBB4 6. "Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways." Mizuki M., Fenski R., Halfter H., Matsumura I., Schmidt R., Muller C., Gruning W., Kratz-Albers K., Serve S., Steur C., Buchner T., Kienast J., Kanakura Y., Berdel W.E., Serve H. Blood96:3907-3914(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION IN RESPONSE TO FLT3 SIGNALING 7. "The intracellular domain of ErbB4 induces differentiation of mammary epithelial cells." Muraoka-Cook R.S., Sandahl M., Husted C., Hunter D., Miraglia L., Feng S.M., Elenius K., Earp H.S. III Mol. Biol. Cell17:4118-4129(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION;SUBCELLULAR LOCATION;INTERACTION WITH ERBB4 8. "Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells." Chaix A., Lopez S., Voisset E., Gros L., Dubreuil P., De Sepulveda P. J. Biol. Chem.286:5956-5966(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION IN RESPONSE TO KIT SIGNALING 9. "Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling." Arora D., Stopp S., Bohmer S.A., Schons J., Godfrey R., Masson K., Razumovskaya E., Ronnstrand L., Tanzer S., Bauer R., Bohmer F.D., Muller J.P. J. Biol. Chem.286:10918-10929(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION IN RESPONSE TO FLT3 SIGNALING 10. "ISG15 modulates development of the erythroid lineage." Maragno A.L., Pironin M., Alcalde H., Cong X., Knobeloch K.P., Tangy F., Zhang D.E., Ghysdael J., Quang C.T. PLoS ONE6:E26068-E26068(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ISGYLATION 11. "Structure of the unphosphorylated STAT5a dimer." Neculai D., Neculai A.M., Verrier S., Straub K., Klumpp K., Pfitzner E., Becker S. J. Biol. Chem.280:40782-40787(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.21 ANGSTROMS) OF 128-712

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