ELISA Kit for Mouse R-spondin-1

Mfr.No.	E3285m
Alternative Names	Cysteine-rich and single thrombospondin domain-containing protein 3 ; Cristin-3 ; Roof plate-specific spondin-1
Categories	Elisa
Function	Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.
Specificity	Natural and recombinant Mouse R-spondin-1
Subcellular Location	Secreted Nucleus May also localize in the nucleus according to PubMed:14732490.
Detection Range	78-5000pg/mL
Entryname	RSPO1_MOUSE
Method Type	Sandwich
Platform	PF00090
Protein Name	R-spondin-1
Sensitivity	40.7pg/mL
Sequence	50: MRLGLCVVAL ; VLSWTHIAVG ; SRGIKGKRQR ; RISAEGSQAC ; AKGCELCSEV ; 100: NGCLKCSPKL ; FILLERNDIR ; QVGVCLPSCP ; PGYFDARNPD ; MNKCIKCKIE ; 150: HCEACFSHNF ; CTKCQEALYL ; HKGRCYPACP ; EGSTAANSTM ; ECGSPAQCEM ; 200: SEWSPWGPCS ; KKRKLCGFRK ; GSEERTRRVL ; HAPGGDHTTC ; SDTKETRKCT ; 250: VRRTPCPEGQ ; KRRKGGQGRR ; ENANRHPARK ; NSKEPRSNSR ; RHKGQQQPQP ; 265: GTTGPLTSVG ; PTWAQ
Sequence Length	265
String	Q9Z132
Sub Unit	Interacts with the extracelular domain of FZD8 and LRP6. It however does not form a ternary complex with FZD8 and LRP6. Interacts with WNT1. Binds heparin.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808505	E3285m	96T	$776		Add to Cart